Essential hypertension: A filtered serum based metabolomics study

Scientific Reports
Keerti AmetaAbbas Ali Mahdi

Abstract

Despite the easy and reliable methods of blood pressure measurement, the screening of essential hypertension (EH) is usually ignored due to delayed onset of symptoms. A probe into the biochemical changes in hypertension would serve as a welcome asset to provide insight into the mechanistic aspects of EH. Filtered serum samples from 64 EH patients and 59 healthy controls (HC) were analysed using 800 MHz nuclear magnetic resonance (NMR) spectroscopy. Application of principal component analysis (PCA) and orthogonal partial least-squares discriminant analysis (OPLS-DA) following receiver operating characteristic (ROC) curve of NMR data reveals significantly perturbed metabolites: alanine, arginine, methionine, pyruvate, adenine, and uracil. This set of metabolites correctly classified 99% of cases from HC and also showed excellent correlation in both isolated elevated diastolic blood pressure (DBP) cases and combined elevated systolic-diastolic blood pressure cases. Proton NMR metabolomics of EH may prove helpful in defining associated biomarkers and serve as an alternate diagnostic tool with judicious clinical assessment.

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Citations

Feb 1, 2020·Journal of Hypertension·William J HeTanika N Kelly
Jul 23, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Donna K Arnett, Gregory A Graf
Jun 21, 2019·Circulation Research·Jasenka ZubcevicMohan K Raizada
Jul 12, 2018·Current Hypertension Reports·Ioanna TzoulakiPaul Elliott
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·S C BooneD O Mook-Kanamori
May 7, 2020·Scientific Reports·Yaya GoïtaPascal Reynier
May 12, 2018·Circulation Research·Donna K Arnett, Steven A Claas
Jan 27, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Yueting DengChaofu Ke
Dec 10, 2020·Clinical Hypertension·John O Onuh, Michel Aliani
Jun 22, 2021·Synthetic and Systems Biotechnology·Jing LiuZhiliang Gao

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Methods Mentioned

BETA
NMR
PCA

Software Mentioned

OPLS
Bruker TopSpin
INTERMAP
Excel
Unscrambler X
Bruker AMIX ( Analysis of MIXtures )
DA

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