PMID: 6138591Oct 29, 1983Paper

Essential hypertension in the elderly: haemodynamics, intravascular volume, plasma renin activity, and circulating catecholamine levels

Lancet
F H MesserliE D Frohlich

Abstract

In an attempt to dissociate the cardiovascular adaptations to high blood pressure from those of ageing, 30 patients with established essential hypertension aged over 65 years were matched for mean arterial pressure, race, sex, height, and weight with 30 patients younger than 42 years. Cardiac output, heart rate, stroke volume, intravascular volume, renal blood flow, and plasma renin activity were significantly lower in the elderly, whereas total peripheral (and renal vascular) resistance, left ventricular posterior wall and septal thicknesses, and left ventricular mass were higher. Intravascular volume correlated inversely with total peripheral resistance in both groups and in all patients. Pathophysiological findings of essential hypertension in the elderly are characterised by a hypertrophied heart of the concentric type with a low cardiac output resulting from a smaller stroke volume and a slower heart rate. Renal blood flow is disproportionally reduced and total peripheral and renal vascular resistance elevated.

References

Nov 1, 1975·Kidney International·P WeidmannJ de Lima
Jan 11, 1975·Lancet·J D Swales
Jul 1, 1976·Progress in Cardiovascular Diseases·G GerstenblithM L Weisfeldt
Jan 27, 1977·The New England Journal of Medicine·C R LakeI J Kopin
Jun 1, 1973·The Journal of Pathology·M S Dunnill, W Halley
Mar 1, 1974·Circulation Research·N K HollenbergJ P Merrill
Jan 1, 1974·Stroke; a Journal of Cerebral Circulation·R B ShekelleH L Klawans
May 1, 1974·American Journal of Public Health·A M OstfeldH M Tufo
Dec 1, 1969·The American Journal of Medicine·N K HollenbergJ P Merrill
Oct 1, 1955·Circulation·M BRANDFONBRENERN W SHOCK

❮ Previous
Next ❯

Citations

Nov 1, 1990·Journal of Clinical Pharmacology·P K ZachariahA G Moore
Jun 1, 1991·Journal of Clinical Pharmacology·T D GilesM A Sirgo
Jan 1, 1991·Cardiovascular Drugs and Therapy·J L Dall
Aug 1, 1993·Cardiovascular Drugs and Therapy·E G LakattaA H Gradman
Jan 1, 1990·European Journal of Clinical Pharmacology·B KrönigB Müller-Beckmann
Oct 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·E Vargas, M Lye
Oct 1, 1991·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·R H Rosenman
Jan 1, 1990·European Journal of Clinical Pharmacology·G Gerstenblith, S P Schulman
Mar 1, 1992·Aging : Clinical and Experimental Research·R S TilvisA Sorva
Jan 6, 2011·Current Atherosclerosis Reports·Alberto Ranieri De Caterina, Antonio Maria Leone
Oct 16, 2002·Current Cardiology Reports·Ehud Grossman, Franz H Messerli
Aug 10, 2007·Current Hypertension Reports·Joseph L Izzo
Dec 14, 1987·The American Journal of Cardiology·D R Abernethy, S C Montamat
Apr 14, 1995·Mechanisms of Ageing and Development·J Marín
Jan 1, 1996·Archives of Gerontology and Geriatrics·G Torrisi, A Distefano
Jan 1, 1989·International Journal of Cardiology·E G Lakatta
Jun 13, 1985·The New England Journal of Medicine·F H MesserliC Amodeo
Nov 26, 2009·Clinical and Experimental Pharmacology & Physiology·I C Moraes-SilvaM C Irigoyen
Jul 31, 2002·The Journal of Clinical Hypertension·L Michael Prisant
May 1, 1991·Special Care in Dentistry : Official Publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry·L FattoreJ M Doherty-Greenberg
Jan 1, 1995·Annual Review of Medicine·N M Kaplan
May 9, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Mohammad W MohiuddinChristopher M Quick
Oct 6, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Dimitrios KonstandonisNikolaos A Zakopoulos
Mar 22, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Satoshi MorimotoAtsuhiro Ichihara
Jan 1, 1986·Current Medical Research and Opinion·A D MarksS Lanzilotti
Oct 3, 2014·Journal of Human Hypertension·S FriedrichR E Schmieder
Aug 1, 2006·São Paulo Medical Journal = Revista Paulista De Medicina·Agbani Ejaife OnoOjo Araoye Adeleke
Aug 31, 1992·The American Journal of Medicine·F H Messerli, F Soria
May 18, 2004·The American Journal of Cardiology·Franz H Messerli, Ehud Grossman
Sep 6, 2005·Primary Care·Michael MaddensAyham Ashkar
Jan 1, 1994·The American Journal of Medicine·H M PerryM Sirgo
May 25, 2011·Therapeutic Advances in Cardiovascular Disease·Joseph L Izzo, Adrienne S Zion
Apr 6, 2018·Journal of Cardiovascular Pharmacology·Eman M SalahStevan P Tofovic
Dec 1, 2017·Herz·J Schrader, B Schrader
Feb 15, 2018·American Journal of Physiology. Renal Physiology·Alissa A Frame, Richard D Wainford
Jan 1, 1996·Hypertension·M KohnoJ Yoshikawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.