Essential oil composition and biological activity from Artemisia caerulescens subsp. densiflora (Viv.) Gamisans ex Kerguélen & Lambinon (Asteraceae), an endemic species in the habitat of La Maddalena Archipelago

Natural Product Research
Luigi OrnanoArmanodoriano Bianco

Abstract

The purpose of this study was to investigate the composition of the essential oil obtained from a population of Artemisia caerulescens subsp. densiflora growing in Razzoli, an island in the La Maddalena Archipelago (Sardinia, Italy). A. caerulescens sups. densiflora Viv. (Asteraceae), a wild herb, seldom studied in the Mediterranean, represents one of the many rare endemic species growing in North Sardinia. The essential oil composition was analysed by means of GC/MS analysis, which showed davana ethers as the major volatile components, accounting together for 17.5%, followed by (E)-nerolidol (4.5%), β-oplopenone (3.3%), cis-sabinene hydrate (5.2%) and terpinen-4-ol (4.7%). The oil was tested for antioxidant activity by means of DPPH test, inhibition of lipid oxidation test and hypochlorous acid test, which showed a quite interesting scavenger capacity. For the first time, we reported the cytotoxic activity of the essential oil of A. caerulescens subsp. densiflora, against three human tumour cell lines (A375, MDA-MB231 and HCT116), with IC50 values in the range 5.20-7.61 μg/mL, which deserved further studies to support its use as chemopreventive agent. Finally, the antimicrobial activity of the essential oil, displayed on a pan...Continue Reading

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Citations

Nov 24, 2016·Natural Product Research·Diego A SampietroCesar A Catalán
Mar 11, 2017·Chemistry & Biodiversity·Alessandro VendittiArmandodoriano Bianco
Apr 4, 2020·Chemistry & Biodiversity·Aleksandar Ž KostićZora P Dajić Stevanović
Dec 11, 2019·Biomolecules·Diogo Vilar da FonsêcaDamião Pergentino de Sousa
Apr 21, 2017·Natural Product Research·Zahra Bagheri FarahaniArian Rahimi
Oct 20, 2020·Journal of Pharmacopuncture·Nour Elhouda Daoudi, Mohamed Bnouham

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