Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Paola PomaMonica Notarbartolo

Abstract

Drug resistance is a major obstacle in antibiotic and antitumor chemotherapy. In response to the necessity to find new therapeutic strategies, plant secondary metabolites including essential oils (EOs) may represent one of the best sources. EOs in plants act as constitutive defenses against biotic and abiotic stress, and they play an important role in the pharmacology for their low toxicity, good pharmacokinetic and multitarget activity. In this context, natural products such as EOs are one of the most important sources of drugs used in pharmaceutical therapeutics. The aim of this paper was to identify the chemical composition of the essential oil of Alluaudia procera leaves, obtained by hydrodistillation and analysed by gas chromatography-mass spectrometry, and to verify its biological activities on acute myeloid leukemia cancer cell HL60 and its multidrugresistant variant HL60R and the Gram-positive Staphylococcus aureus exhibiting multi-antibiotic resistance. We speculate that cytotoxic and antibiotic effects observed in the tested resistant models may be due to the coordinate activities of forty compounds detected or to the C16 macrocyclic lactones which are the major ones (30%). Our data confirm the possibility of using EO...Continue Reading

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Citations

Apr 29, 2020·Materials·Maria Luisa SaladinoMagdalena Wawrzyńska
Jun 4, 2020·Antibiotics·Maria Valeria RaimondiPatrizia Cancemi
May 1, 2020·International Journal of Molecular Sciences·Manuela LabbozzettaPaola Poma
Oct 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simona RubinoIvana Pibiri

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