Essential oil-mediated glycerosomes increase transdermal paeoniflorin delivery: optimization, characterization, and evaluation in vitro and in vivo

International Journal of Nanomedicine
Kai ZhangNian-Ping Feng

Abstract

In this study, a novel glycerosome carrier containing essential oils was prepared for topical administration of paeoniflorin (PF) to enhance its transdermal drug delivery and improve drug absorption in the synovium. The formulation of glycerosomes was optimized by a uniform design, and the final vehicle was composed of 5% (w/v) phospholipid, 0.6% (w/v) cholesterol, and 10% (v/v) glycerol, with 2% (v/v) Speranskia tuberculata essential oil (STO) as the transdermal enhancer. The in vitro transdermal flux of PF loaded in the STO-glycerosomes was 1.4-fold, 1.6-fold, and 1.7-fold higher than those of glycerosomes, liposomes, and tinctures, respectively. In vivo studies showed that the use of STO-glycerosomes was associated with a 3.1-fold greater accumulation of PF in the synovium than that of common glycerosomes. This finding was confirmed by in vivo imaging studies, which found that the fluorescence intensity of Cy5.5-loaded STO-glycerosomes in mice knee joints was 1.8-fold higher than that of the common glycerosomes 5 h after administration. The glycerosomes mediated by STO exhibited considerable skin permeability as well as improved drug absorption in the synovium, indicating that STO-glycerosomes may be a potential PF transderm...Continue Reading

Citations

Dec 24, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yahua CuiShouying Du
Nov 30, 2018·The American Journal of Chinese Medicine·Lei LiLan Shen
Jul 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giulia VantiAnna Rita Bilia
Dec 12, 2020·Drug Development and Industrial Pharmacy·Chengying ShenXiaofang Li
Apr 11, 2020·International Journal of Pharmaceutics·Marianne J NaguibShaimaa M Badr-Eldin
May 8, 2020·International Journal of Pharmaceutics·Francesco LaiAnna Maria Fadda
Aug 16, 2021·International Journal of Pharmaceutics·Marianne J NaguibWessam H Abd-Elsalam
Nov 4, 2021·Journal of Liposome Research·Manish Kumar GuptaPrashant Gurav

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Methods Mentioned

BETA
dynamic light scattering
fluorescence imaging
transmission electron microscopy

Software Mentioned

SPSS
Lumina II Living Image

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