PMID: 15387375Sep 25, 2004Paper

Essential role for hematopoietic Fas ligand (FasL) in the suppression of melanoma lung metastasis revealed in bone marrow chimeric mice

Clinical & Experimental Metastasis
Christopher L HallLaurie B Owen-Schaub

Abstract

The outcome of cancer metastasis depends on multiple interactions between the malignant cell and the host environment. Such interactions can influence primary cancer growth and metastasis by altering the balance between tumor cell proliferation and death. We have previously reported that the pro-apoptotic protein FasL could potently suppress spontaneous lung metastasis of the Fas-sensitive melanoma, K1735-P. In this report, we have constructed bone marrow chimeric mice using wt and FasL-deficient animals to delineate the source of FasL (hematopoietic or nonhematopoietic) required to control spontaneous metastatic spread from a subcutaneous tumor. Using FasL-deficient animals (gld) reconstituted with wt FasL bone marrow (wt --> gld), and wt animals reconstituted with FasL-derived bone marrow (gld --> wt), we show, for the first time, an essential role for hematopoietic-derived FasL in the suppression of K1735-P metastasis. When FasL was expressed only in the nonhematopoietic compartment (gld --> wt), K1735-P spread was ineffectively controlled with a metastatic phenotype similar to that observed in animals completely lacking FasL (gld --> gld or gld controls). These studies provide evidence for the indispensable role for FasL+ b...Continue Reading

Citations

Apr 14, 2012·Biochimica Et Biophysica Acta·Frederik J H HoogwaterOnno Kranenburg
Sep 27, 2018·Journal of Cellular and Molecular Medicine·Buqing Sai, Juanjuan Xiang
Mar 16, 2006·Pharmacogenetics and Genomics·Chunying LiQingyi Wei

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