Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection.

Arteriosclerosis, Thrombosis, and Vascular Biology
Yajing WangXin-Liang Ma

Abstract

Adiponectin (APN) system malfunction is causatively related to increased cardiovascular morbidity/mortality in diabetic patients. The aim of the current study was to investigate molecular mechanisms responsible for APN transmembrane signaling and cardioprotection. Compared with wild-type mice, caveolin-3 knockout (Cav-3KO) mice exhibited modestly increased myocardial ischemia/reperfusion injury (increased infarct size, apoptosis, and poorer cardiac function recovery; P<0.05). Although the expression level of key APN signaling molecules was normal in Cav-3KO, the cardioprotective effects of APN observed in wild-type were either markedly reduced or completely lost in Cav-3KO. Molecular and cellular experiments revealed that APN receptor 1 (AdipoR1) colocalized with Cav-3, forming AdipoR1/Cav-3 complex via specific Cav-3 scaffolding domain binding motifs. AdipoR1/Cav-3 interaction was required for APN-initiated AMP-activated protein kinase (AMPK)-dependent and AMPK-independent intracellular cardioprotective signalings. More importantly, APPL1 and adenylate cyclase, 2 immediately downstream molecules required for AMPK-dependent and AMPK-independent signaling, respectively, formed a protein complex with AdipoR1 in a Cav-3 dependent ...Continue Reading

References

Feb 21, 2002·Trends in Endocrinology and Metabolism : TEM·Anders H BergPhilipp E Scherer
Aug 29, 2003·The Journal of Biological Chemistry·Hui ChenMichael J Quon
Nov 11, 2003·American Journal of Physiology. Endocrinology and Metabolism·Alex W CohenMichael P Lisanti
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher HugHarvey F Lodish
Aug 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jin OshikawaYoshihiro Ishikawa
May 26, 2005·Cellular Signalling·Yoshihiro IshikawaJin Oshikawa
Jan 18, 2006·Cardiovascular Research·Carsten SchwenckeRuth H Strasser
Jun 20, 2006·Trends in Cardiovascular Medicine·Noriyuki OuchiKenneth Walsh
Jul 4, 2006·Cell Metabolism·Sarah E HoschJane J Kim
Jul 11, 2006·The Journal of Clinical Investigation·Takashi KadowakiKazuyuki Tobe
Jan 24, 2007·Physiological Reviews·Karen Bedard, Karl-Heinz Krause
Nov 26, 2008·Nature Clinical Practice. Cardiovascular Medicine·Barry J GoldsteinXin L Ma
Apr 29, 2009·Molecular and Cellular Biology·Koji OhashiKenneth Walsh
Nov 20, 2009·American Journal of Physiology. Cell Physiology·Koji OtsuYoshihiro Ishikawa
Mar 6, 2010·Cardiovascular Research·John H Chidlow, William C Sessa
Nov 3, 2010·The Journal of Clinical Investigation·Martin S DenzelBarbara Ranscht
May 28, 2011·Journal of the American College of Cardiology·Yousuke T HorikawaDavid M Roth

❮ Previous
Next ❯

Citations

Jan 15, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Jennifer L Parker-Duffen, Kenneth Walsh
Feb 14, 2013·Journal of Cardiovascular Pharmacology·Ketul R ChaudharyJohn M Seubert
Jun 11, 2016·Basic Research in Cardiology·Yang YangWei Yi
Jul 22, 2016·British Journal of Pharmacology·Louise E See HoeJason N Peart
Jul 27, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Louise E See HoeJason N Peart
Oct 22, 2016·American Journal of Physiology. Cell Physiology·Adam KassanHemal H Patel
May 3, 2018·The Journal of Cell Biology·WooRam JungRobert G Parton
Apr 20, 2014·The Journal of Biological Chemistry·Jennifer L Parker-DuffenKenneth Walsh
Sep 3, 2020·Einstein·Mariela Carolina Santos CarballoMarcus Vinicius Henriques Brito
Jan 21, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lei CaiYou-Yang Zhao
Aug 17, 2020·Communications Biology·Hiroaki TanabeShigeyuki Yokoyama
Oct 17, 2013·American Journal of Physiology. Endocrinology and Metabolism·Yanqing ZhangXin-Liang Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Caveolins & Signal Transduction

Caveolins are small proteins with a hairpin loop conformation that are located in the plasma membrane of various cell types where they bind cholesterol and interact with receptors essential for several signal transduction pathways. Here is the latest research.