Essential role of dendritic cell CD80/CD86 costimulation in the induction, but not reactivation, of TH2 effector responses in a mouse model of asthma

The Journal of Allergy and Clinical Immunology
Leonie S van RijtBart N Lambrecht

Abstract

Airway dendritic cells (DCs) are crucial for the generation of TH2 cells from naive T cells during sensitization and for reactivation of primed TH2 cells on allergen challenge in mouse models of asthma. It is unknown whether CD80/CD86 costimulation is necessary during both phases of the response because primed T cells rely less on costimulatory molecules compared with naive T cells. We sought to study the contribution of CD80/CD86 costimulatory molecules on DCs during sensitization or challenge in a mouse model of asthma. Naive BALB/c mice received an intratracheal injection of ovalbumin (OVA)-pulsed DCs obtained from the bone marrow of wild-type (WT) or CD80/CD86-/- mice and were subsequently challenged with OVA aerosol to address the role of costimulation during sensitization. OVA-sensitized mice received OVA-pulsed WT or CD80/CD86-/- DCs without OVA aerosol to address the role of costimulation during challenge. WT DCs induced the proliferation and effector TH2 differentiation of naive OVA-specific T cells, whereas CD80/CD86-/- DCs induced only proliferation. Not surprisingly, WT DCs but not CD80/CD86-/- DCs induced sensitization to OVA in naive mice. In contrast, in OVA-sensitized mice intratracheal injection of CD80/CD86-/-...Continue Reading

References

Apr 15, 1997·Transplantation·D E SpeiserP S Ohashi
Oct 6, 1997·American Journal of Respiratory Cell and Molecular Biology·A J Van OosterhoutF P Nijkamp
May 2, 1998·American Journal of Respiratory Cell and Molecular Biology·P A PadridJ A Bluestone
Aug 28, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D S Robinson
Jun 22, 1999·Current Opinion in Immunology·T H Watts, M A DeBenedette
Jul 28, 1999·International Immunology·P BertolinoC Rabourdin-Combe
Aug 23, 2000·The Journal of Clinical Investigation·B N LambrechtR A Pauwels
Mar 17, 2001·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B N Lambrecht
Mar 22, 2002·Nature Reviews. Immunology·M L AlegreC B Thompson
Mar 26, 2002·Nature Reviews. Immunology·Arlene H Sharpe, Gordon J Freeman
Jul 4, 2002·International Immunology·Jeanette E ChristensenAllan R Thomsen
Nov 20, 2002·The Journal of Clinical Investigation·Stephanie L ConstantKim Bottomly
Dec 4, 2002·Nature Reviews. Immunology·Antonio Lanzavecchia, Federica Sallusto
Mar 18, 2003·Nature Immunology·Amanda V GettJens Geginat
Apr 19, 2003·American Journal of Respiratory Cell and Molecular Biology·Karim Vermaelen, Romain Pauwels
Jul 16, 2003·The Journal of Experimental Medicine·Shahram Salek-ArdakaniMichael Croft
Sep 6, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D T DeurlooA J M van Oosterhout
Dec 4, 2003·Nature Reviews. Immunology·Bart N Lambrecht, Hamida Hammad

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Citations

Feb 3, 2005·Current Allergy and Asthma Reports·Abdelouahab Bellou, Patricia W Finn
May 28, 2008·Expert Reviews in Molecular Medicine·Bennett O V ShumWilliam A Sewell
Dec 17, 2008·Mucosal Immunology·C H GeurtsvanKessel, B N Lambrecht
Nov 19, 2004·Current Opinion in Pediatrics·Stephanie C EisenbarthKim Bottomly
Dec 1, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Zoran D RistovskiIan A Yang
May 13, 2011·American Journal of Respiratory and Critical Care Medicine·Leonie S van RijtBart N Lambrecht
Jan 19, 2013·American Journal of Respiratory and Critical Care Medicine·Thorsten DürkMarco Idzko
Jan 20, 2009·American Journal of Respiratory Cell and Molecular Biology·Toshiyuki KoyaErwin W Gelfand
Nov 3, 2006·The Journal of Clinical Investigation·Marco IdzkoBart N Lambrecht
Feb 3, 2007·The Journal of Clinical Investigation·Marco IdzkoBart N Lambrecht
Nov 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Anjali J de SouzaLawrence P Kane
Jan 10, 2012·Annual Review of Immunology·Bart N Lambrecht, Hamida Hammad
Oct 7, 2010·Expert Review of Respiratory Medicine·Kanami OriharaRedwan Moqbel
May 6, 2015·Molecular Medicine Reports·Shao-Lin ZengJiong Yang
Oct 27, 2014·Respiratory Research·Yukari Asai-TajiriYoichi Nakanishi
Aug 19, 2009·Pharmacology & Therapeutics·Jennifer T BurchellPhilip A Stumbles
Feb 18, 2014·European Journal of Immunology·Ivan K H PoonMark D Hulett
Mar 4, 2008·The Journal of Allergy and Clinical Immunology·Colin de HaarRaymond Pieters
Nov 6, 2007·Current Opinion in Immunology·Mirjam Kool, Bart N Lambrecht
Sep 17, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L S van Rijt, B N Lambrecht
May 23, 2006·International Journal of Immunogenetics·A M AbdallahK I Welsh
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Stephen T Holgate
Nov 20, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M A M Willart, B N Lambrecht
Jul 15, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S RochlitzerA Braun
Sep 21, 2010·European Journal of Immunology·Maud PlantingaBart N Lambrecht
Oct 30, 2004·Current Opinion in Immunology·Harmjan Kuipers, Bart N Lambrecht
Jun 22, 2005·Seminars in Immunology·Hendrik Jan de HeerBart N Lambrecht
Jun 9, 2015·The Journal of Allergy and Clinical Immunology·Marco IdzkoClive Page
Feb 25, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Monique A M Willart, Hamida Hammad
Sep 22, 2009·Immunity·Bart N Lambrecht, Hamida Hammad
Sep 30, 2010·Yonsei Medical Journal·Sebastian ReuterChristian Taube

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