PMID: 22553833May 4, 2012Paper

Essential role of hormone-sensitive lipase (HSL) in the maintenance of lipid storage in Mycobacterium leprae-infected macrophages

Microbial Pathogenesis
Kazunari TanigawaKoichi Suzuki

Abstract

Mycobacterium leprae (M. leprae), the causative agent of leprosy, parasitizes within the foamy or enlarged phagosome of macrophages where rich lipids accumulate. Although the mechanisms for lipid accumulation in the phagosome have been clarified, it is still unclear how such large amounts of lipids escape degradation. To further explore underlying mechanisms involved in lipid catabolism in M. leprae-infected host cells, we examined the expression of hormone-sensitive lipase (HSL), a key enzyme in fatty acid mobilization and lipolysis, in human macrophage THP-1 cells. We found that infection by live M. leprae significantly suppressed HSL expression levels. This suppression was not observed with dead M. leprae or latex beads. Macrophage activation by peptidoglycan (PGN), the ligand for toll-like receptor 2 (TLR2), increased HSL expression; however, live M. leprae suppressed this increase. HSL expression was abolished in the slit-skin smear specimens from patients with lepromatous and borderline leprosy. In addition, the recovery of HSL expression was observed in patients who experienced a lepra reaction, which is a cell-mediated, delayed-type hypersensitivity immune response, or in patients who were successfully treated with mult...Continue Reading

References

Jun 1, 1976·Japanese Journal of Medical Science & Biology·E Kondo, K Kanai
Jul 20, 1990·European Journal of Biochemistry·A J Garton, S J Yeaman
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J ChanB R Bloom
Aug 10, 2000·Scandinavian Journal of Immunology·P J CardonaV Ausina
Nov 21, 2000·The Journal of Biological Chemistry·N E WolinsD L Brasaemle
Mar 10, 2001·Nature·S T ColeB G Barrell
Jan 17, 2002·Microbiology and Immunology·S SasakiN Ishii
May 1, 2002·Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association·Yasuko YogiHiroko Nomaguchi
Apr 15, 2003·Nature Medicine·Stephan R KrutzikRobert L Modlin
Jun 18, 2003·The Journal of Cell Biology·Carole SztalrydConstantine Londos
Jul 2, 2003·The Journal of Biological Chemistry·Chun-Li SuConstantine Londos
Apr 3, 2004·Journal of Lipid Research·Mohamad NavabAlan M Fogelman
Aug 5, 2004·The Journal of Biological Chemistry·Vidya SubramanianDawn L Brasaemle
Mar 1, 2007·Acta Histochemica Et Cytochemica·Koichi SuzukiMasahiko Makino
Mar 16, 2007·The Journal of Clinical Endocrinology and Metabolism·Johan W E JockenEllen E Blaak
Jul 19, 2008·The Journal of Clinical Investigation·Daniel CruzRobert L Modlin
Nov 18, 2008·Biochimica Et Biophysica Acta·Robert ZimmermannRudolf Zechner
Sep 1, 2009·Journal of Bacteriology·Anna BrzostekJaroslaw Dziadek
Jun 18, 2010·Microbial Pathogenesis·Takeshi AkamaKoichi Suzuki
Jul 3, 2010·EMBO Molecular Medicine·Mi-Jeong KimDavid G Russell
Aug 17, 2010·Biochemical and Biophysical Research Communications·Junetsu OgasawaraHideki Ohno

❮ Previous
Next ❯

Citations

Dec 18, 2013·Future Microbiology·Yang DegangKoichi Suzuki
Dec 5, 2015·Journal of Mass Spectrometry : JMS·Cristiana S de MacedoMaria Cristina V Pessolani
Mar 17, 2015·Cellular Microbiology·Caroline BarischThierry Soldati
Mar 14, 2017·Future Microbiology·Gurkamaljit Kaur, Jagdeep Kaur
Jan 31, 2014·Infection and Immunity·Olivier Neyrolles
Jul 23, 2014·Antimicrobial Agents and Chemotherapy·Lívia Silva LobatoFlávio Alves Lara
Aug 29, 2013·Current Opinion in Infectious Diseases·Anastasia PolycarpouDiana N Lockwood
Sep 26, 2019·Journal of Medical Microbiology·Ruchi RastogiJagdeep Kaur
Jul 25, 2021·International Journal of Molecular Sciences·Kazunari TanigawaKoichi Suzuki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.