Essential role of PDZ-RGS3 in the maintenance of neural progenitor cells.

Stem Cells
Runxiang QiuQiang Lu

Abstract

Ephrin-B plays an important role in neural progenitor cells to regulate self-renewal and differentiation. Cellular and embryological evidence suggest this function of ephrin-B is mediated through a PDZ-dependent reverse signaling mechanism. Here, we have genetically investigated the function of PDZ-RGS3, a proposed downstream signaling mediator of ephrin-B function, and found that knockout of PDZ-RGS3 caused early cell cycle exit and precocious differentiation in neural progenitor cells of the developing cerebral cortex, reminiscent of the phenotype observed in ephrin-B1 knockout mice. This resulted in a loss of cortical neural progenitor cells during cortical neurogenesis and led to impairment in the production of late born cortical neurons. These results reveal an essential role of PDZ-RGS3 in maintaining the balance between self-renewal and differentiation of neural progenitor cells and provide genetic evidence linking PDZ-RGS3 to ephrin-B reverse signaling. As ephrin-B molecules are often differentially expressed in different types of neural progenitor/stem cells during development or in adult life, deletion of PDZ-RGS3 can achieve a uniform loss of function of the ephrin-B/regulator of G protein-signaling (RGS) pathway, th...Continue Reading

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Mar 9, 2013·Archives of Biochemistry and Biophysics·Srinivas RamasamySohail Ahmed
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Dec 9, 2014·Cell Adhesion & Migration·Bethany E Perez White, Spiro Getsios
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Aug 31, 2020·Cerebral Cortex Communications·Runxiang QiuQiang Lu
Oct 22, 2019·Frontiers in Molecular Biosciences·Min JiangBaosen Zhou

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