Essential role of spi-1-like (spi-1l) in zebrafish myeloid cell differentiation.

Blood
Alex BukrinskyUtpal Banerjee

Abstract

The ETS protein Spi-1/Pu.1 plays a pivotal and widespread role throughout hematopoiesis in many species. This study describes the identification, characterization, and functional analysis of a new zebrafish spi transcription factor spi-1-like (spi-1l) that is expressed in primitive myeloid cells, erythro-myelo progenitor cells, and in the adult kidney. Spi-1l functions genetically downstream of etsrp, scl, and spi-1/pu.1 in myeloid differentiation. Spi-1l is coexpressed in a subset of spi-1/pu.1 cells and its function is necessary and sufficient for macrophage and granulocyte differentiation. These results establish a critical role for spi-1l in zebrafish myeloid cell differentiation.

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Citations

Sep 8, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Li WangQing Kenneth Wang
May 10, 2019·Frontiers in Cell and Developmental Biology·Craig M NelsonJohn R Henley
Jun 12, 2013·Developmental and Comparative Immunology·Barbara A KatzenbackMiodrag Belosevic
Aug 7, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jesús García-CastilloMaría L Cayuela

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