PMID: 6171709Jan 1, 1981Paper

Essential Role of T cells in the postexposure prophylaxis of rabies in mice

Microbiology and Immunology
K MifuneK Sakamoto

Abstract

Athymic nude mice injected intramuscularly with a street stain of rabies virus were not protected against rabies by postexposure administration of beta-propiolactone-inactivated rabies vaccine. In contrast, their normal littermates were completely protected from death by the same vaccination regimens. Nude mice did not produce IgG antibody as a result of the vaccine during the test period of 15 days, whereas normal littermates produced IgG antibody from day 5 after vaccination. However, passive immunization with antirabies hyperimmune mouse ascites showed that antibody was completely ineffective in protecting either nude mice or their normal littermates against rabies when given later than 2 days after infection. No significant difference in the induction of circulating interferon by the vaccination was noted in these mice. Passive transfer of immune spleen cells to nude mice immediately after infection resulted in 30 to 37.5% protection of the mice. Passively transferred spleen cells did not produce detectable amounts of neutralizing antibody in the recipient mice except on day 2 after the transfer, when a low level of antibody was detected. These observations demonstrate the essential role of T cells in the postexposure proph...Continue Reading

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Citations

Aug 1, 1990·Vaccine·M L JoffretP Perrin
Apr 1, 1991·Biologicals : Journal of the International Association of Biological Standardization·M L JoffretP Perrin
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J H NunbergC J York
Jan 1, 1992·Microbiology and Immunology·K HiraiK Mannen
Aug 17, 2012·Journal of Virology·Corin L DorfmeierJames P McGettigan
Jun 14, 2013·Journal of Virology·Andrew G LytleJames P McGettigan
Jun 14, 2013·Journal of Virology·Corin L DorfmeierJames P McGettigan
Mar 22, 2013·PLoS Neglected Tropical Diseases·Corin L DorfmeierJames P McGettigan
Jan 24, 2007·PLoS Pathogens·Heinz FeldmannThomas W Geisbert
Dec 15, 2015·The Journal of Infectious Diseases·Kentaro YamadaAkira Nishizono
Jan 1, 1989·Revista Do Instituto De Medicina Tropical De São Paulo·C R ZanettiO A Pereira
Apr 23, 2008·Microbiology and Immunology·Akira NishizonoKinjiro Morimoto
Apr 16, 2003·American Journal of Veterinary Research·Peter S WunderliGeorge M Baer
Jul 18, 2003·The Journal of General Virology·Kate AspdenAnna-Lise Williamson
Aug 1, 1991·Clinical and Experimental Immunology·M HerzogM Lafon

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