Essential role of the posterior morphogen nanos for germline development in Drosophila

Nature
S KobayashiT Kitamura

Abstract

In many animal groups, factors required for germline formation are localized in germ plasm, a region of the egg cytoplasm. In Drosophila embryos, germ plasm is located in the posterior pole region and is inherited in pole cells, the germline progenitors. Transplantation experiments have demonstrated that germ plasm contains factors that can form germline, and germ plasm also directs abdomen formation. Genetic analysis has shown that a common mechanism directs the localization of the abdomen and germline-forming factors to the posterior pole. The critical factor for abdomen formation is the nanos (nos) protein (nanos). Here we show that nos is also essential for germline formation in Drosophila; pole cells lacking nanos activity fail to migrate into the gonads, and so do not become functional germ cells. In such pole cells, gene expression, which normally initiates within the gonad, begins prematurely during pole-cell migration. Premature activation of genes in germline precursors may mean that these cells fail to develop normally. A function for nos protein in Drosophila germline formation is compatible with observations of its association with germ plasm in other animals.

References

Jan 1, 1975·International Review of Cytology·E M Eddy
Jan 1, 1976·Experimental Cell Research·K Illmensee, A P Mahowald
Jul 30, 1992·Nature·A Ephrussi, R Lehmann
Nov 1, 1987·Genes & Development·B OliverA P Mahowald
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·K Illmensee, A P Mahowald
Feb 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C WangR Lehmann
Jul 1, 1993·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·S Kobayashi, M Okada
Jul 1, 1986·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Trudi Schüpbach, Eric Wieschaus

❮ Previous
Next ❯

Citations

Jan 1, 1996·Developmental Genetics·M L King
Apr 25, 2012·Development Genes and Evolution·Paula Rezende-TeixeiraGláucia Maria Machado-Santelli
Nov 23, 2010·Cell and Tissue Research·Konstantin V YakovlevNelly A Odintsova
Feb 23, 2002·Trends in Genetics : TIG·Marvin WickensRoy Parker
Sep 3, 1999·Mechanisms of Development·H MacArthurM L King
Aug 21, 2002·Trends in Cell Biology·Pernille Rørth
Sep 3, 2003·Nature Reviews. Genetics·Erez Raz
Dec 17, 2004·Biology of the Cell·Mary Lou KingKimberly L Mowry
May 1, 1998·Development, Growth & Differentiation·K Ikenishi
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Atsushi SuzukiYumiko Saga
Mar 23, 2011·Human Molecular Genetics·Vanessa T Angeles Julaton, Renee A Reijo Pera
Jul 20, 2011·Cold Spring Harbor Perspectives in Biology·Ekaterina VoroninaIppei Nagamori
Sep 17, 2010·Genes & Development·Yuying WangPhillip A Newmark
Mar 29, 2001·Genes & Development·J Sonoda, R P Wharton
Apr 1, 2006·Development, Growth & Differentiation·Hiromi KurokawaMinoru Tanaka
Nov 23, 2006·Development, Growth & Differentiation·Kimihiro SatoKenji Watanabe
Sep 17, 2009·Evolution & Development·Celina E Juliano, Gary M Wessel
Apr 3, 1999·The Journal of Eukaryotic Microbiology·X Yang, M Takahashi
Oct 6, 1998·Annual Review of Biochemistry·A BashirullahH D Lipshitz
Jan 1, 1996·Annual Review of Cell and Developmental Biology·A Williamson, R Lehmann
Nov 1, 2001·Annual Review of Cell and Developmental Biology·I M Palacios, D St Johnston
Jan 1, 1997·Annual Review of Genetics·M de CuevasA C Spradling
Mar 1, 2006·BMC Developmental Biology·Peter K Dearden
Apr 30, 2013·BMC Genomics·Jean-Michel CarterCasper J Breuker
Nov 26, 2010·Development·Celina E JulianoGary M Wessel
Dec 24, 2010·Development·Mamiko Yajima, Gary M Wessel
Apr 18, 1998·Genes & Genetic Systems·M Okada
May 25, 2002·Zoological Science·Masahiro TomiokaHiroki Nishida
Oct 13, 2005·Zoological Science·Satoru KobayashiYoshiki Hayashi
Oct 16, 2013·Zoological Science·Toshie MatsumotoMasahiko Awaji
May 17, 2013·International Journal of Biological Sciences·Guijun GuanYunhan Hong
Apr 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kimihiro SatoSatoru Kobayashi
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·A BashirullahH D Lipshitz
Mar 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yuying WangPhillip A Newmark
Jul 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yoshiki HayashiSatoru Kobayashi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.