Essential Roles for the Non-Canonical IκB Kinases in Linking Inflammation to Cancer, Obesity, and Diabetes

Cells
Chong Hyun Shin, Doo-Sup Choi

Abstract

Non-canonical IκB kinases (IKKs) TBK1 and IKKε have essential roles as regulators of innate immunity and cancer. Recent work has also implicated these kinases in distinctively controlling glucose homeostasis and repressing adaptive thermogenic and mitochondrial biogenic response upon obesity-induced inflammation. Additionally, TBK1 and IKKε regulate pancreatic β-cell regeneration. In this review, we summarize current data on the functions and molecular mechanisms of TBK1 and IKKε in orchestrating inflammation to cancer, obesity, and diabetes.

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Citations

Aug 23, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kazem NouriXiaolong Yang
Sep 24, 2020·Expert Opinion on Therapeutic Targets·Or-Yam RevachRussell W Jenkins
Nov 11, 2020·Scientific Reports·Yun-Fang JiaChong Hyun Shin
Nov 17, 2020·Frontiers in Immunology·Peng Zhao, Alan R Saltiel
Nov 18, 2020·Journal of Experimental & Clinical Cancer Research : CR·Boxiang ZhangSida Qin
Sep 4, 2021·Journal of Medicinal Chemistry·Ricardo A M SerafimMatthias Gehringer
Sep 29, 2021·Cellular Oncology (Dordrecht)·Jhih-Yun HoChia-Hsiung Cheng

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Methods Mentioned

BETA
nuclear translocation
nucleotide exchange
xenograft
targeted knockout
transgenic
dissection
ubiquitination

Clinical Trials Mentioned

NCT01975935

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