PMID: 9445067Jan 28, 1998Paper

Essential roles of NF-kappaB and C/EBP in the regulation of intercellular adhesion molecule-1 after respiratory syncytial virus infection of human respiratory epithelial cell cultures

Journal of Virology
B A ChiniJ M Stark

Abstract

To determine the molecular mechanism(s) of respiratory syncytial virus (RSV)-induced intercellular adhesion molecule-1 (ICAM-1) upregulation in respiratory epithelial cells (REC; A549 cell cultures), we investigated the roles of the transcription factors NF-kappaB and C/EBP. Increases in ICAM-1 message required de novo mRNA synthesis. ICAM-1 promoter constructs (luciferase reporter gene) transfected into A549 monolayers demonstrated promoter activation following RSV infection. Activation was abolished by site-specific mutation of the NF-kappaB (-228) or C/EBP (-239) sites. These data support the critical role of the activation of NF-kappaB and C/EBP in RSV-induced ICAM-1 expression by REC.

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Citations

Feb 13, 2004·FEBS Letters·Xiaoyuan KongShyam S Mohapatra
Apr 22, 2006·Journal of Medical Virology·James M StarkAnn Marie LeVine
May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Isabelle AngersDanielle Malo
Dec 18, 2009·Journal of Virology·James M StarkDaniel R Prows
Jul 29, 2004·Viral Immunology·Subramaniam KrishnanRobert C Welliver
Jul 16, 2008·Clinical Microbiology Reviews·Shyam S Mohapatra, Sandhya Boyapalle
Aug 16, 2008·American Journal of Respiratory Cell and Molecular Biology·Lori J ManzelDwight C Look
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristen PageSvetlana Iasvoyskaia
Nov 3, 2011·The Journal of Endocrinology·Abraham B Roos, Magnus Nord
May 25, 2013·Annals of Medicine·Runyi A LamStephan Gasser
Sep 10, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tobias N Cassel, Magnus Nord
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ralf Arnold, Wolfgang König
Aug 6, 2005·Cell Death and Differentiation·L de Léséleuc, F Denis
Oct 12, 2010·Clinical and Vaccine Immunology : CVI·Keyi LiuMichael Pichichero
Oct 7, 2003·The Journal of Biological Chemistry·Qingding WangB Mark Evers
Dec 31, 2010·Endocrinology·Adam HinzeyJeanette I Webster Marketon
Jul 18, 2012·Antioxidants & Redox Signaling·Roberto P GarofaloAntonella Casola
Nov 7, 2007·Clinical Reviews in Allergy & Immunology·Robert C Welliver
Sep 22, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·T L Noah, S Becker

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