PMID: 6967259Jan 1, 1980Paper

Essential thrombocythemia in a child: platelet ultrastructure and function

American Journal of Hematology
M I BarnhartJ M Lusher

Abstract

A nine-year-old black girl with essential thrombocythemia developed hemoptysis. Only two other cases in the English literature have been described. Ultrastructure and functional characteristics of this patient's platelets were studied. Twenty-six percent of the patient's platelets were very large (megathrombocytes). Spontaneous aggregated from the patient's platelets were not compact, and the pseudopods did not interdigitate. Both qualitative and quantitative defects in platelet organelles were detected. The microtubular system was faulty in organization. Furthermore, the number of granules (especially alpha granules) was reduced. Platelet aggregation studies demonstrated subnormal aggregation in response to ADP, epinephrine, and collagen, but aggregation with ristocetin was normal. It is postulated that a platelet membrane abnormality may be the cause of their defective platelet aggregation.

References

Oct 27, 1972·Annals of the New York Academy of Sciences·J G White
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Jul 1, 1973·The Journal of Pediatrics·M H FreedmanL Weinstein
Nov 1, 1973·The Journal of Cell Biology·L G TilneyD H Snyder
Jan 1, 1969·Acta Haematologica·L J Simar, J Hugues
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May 1, 1960·The American Journal of Medicine·F L OZERW C LEVIN

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Citations

Dec 22, 1999·British Journal of Haematology·Y Dror, V S Blanchette
Nov 1, 1996·Journal of Pediatric Hematology/oncology·G KapoorL C Yu
Oct 19, 1999·Journal of Pediatric Hematology/oncology·Y DrorV S Blanchette
Apr 1, 1995·British Journal of Haematology·M KikuchiA Ohsaka
Feb 1, 1986·Scandinavian Journal of Haematology·S WoessnerL Florensa

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