Essential thrombocythemia, polycythemia vera, and myelofibrosis: current management and the prospect of targeted therapy

American Journal of Hematology
A Tefferi

Abstract

The recent discovery of JAK2 and/or MPL mutations in polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) has had a major impact on how we diagnose and treat these disorders. For instance, the presence of a JAK2 mutation is now considered conditio sine qua non for the diagnosis of PV and the World Health Organization classification system has recently revised its diagnostic criteria for PV, ET, and PMF to include JAK2 and MPL mutations as clonal markers. From the standpoint of treatment, JAK-STAT is now identified as a legitimate target pathway for drug development in myeloproliferative neoplasms. Herein, I will first outline my views regarding current management in ET, PV, and PMF and then discuss emerging data on preclinical and clinical activity of anti-JAK2 small molecule drugs. Am. J. Hematol., 2008. (c) 2008 Wiley-Liss, Inc.

References

Mar 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S CortelazzoT Barbui
Oct 1, 1988·European Journal of Haematology·E Löfvenberg, A Wahlin
Jan 1, 1987·British Journal of Haematology·A D'EmilioE Dini
Dec 1, 1995·Mayo Clinic Proceedings·R P BartlettV F Trastek
Apr 27, 1995·The New England Journal of Medicine·S CortelazzoT Barbui
Jun 1, 1997·British Journal of Haematology·F CervantesE Montserrat
Jan 1, 1997·Seminars in Thrombosis and Hemostasis·M A Elliott, A Tefferi
Apr 27, 2000·The New England Journal of Medicine·A Tefferi
Sep 9, 2000·The New England Journal of Medicine·J Benbassat
May 15, 2001·European Journal of Haematology·C A Wright, A Tefferi
Feb 19, 2002·British Journal of Haematology·M C PettiF Mandelli
Mar 12, 2002·British Journal of Haematology·Francesco PassamontiMario Lazzarino
Apr 26, 2002·British Journal of Haematology·Michelle A ElliottAyalew Tefferi
Feb 14, 2003·Mayo Clinic Proceedings·Ayalew Tefferi
May 24, 2003·Best Practice & Research. Clinical Haematology·Michelle A Elliott, Ayalew Tefferi
May 24, 2003·The Hematology Journal : the Official Journal of the European Haematology Association·Jean-Jacques KiladjianJean-François Bernard
Aug 16, 2003·Blood·H Joachim DeegFrederick R Appelbaum
Nov 1, 1962·Acta Medica Scandinavica·E CHIEVITZ, T THIEDE
Jan 9, 2004·The New England Journal of Medicine·Raffaele LandolfiUNKNOWN European Collaboration on Low-Dose Aspirin in Polycythemia Vera Investigators
Jan 31, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monia MarchettiBrigitte Dupriez
Jul 13, 2004·Mayo Clinic Proceedings·Ruben A MesaAyalew Tefferi
Jan 26, 2005·British Journal of Haematology·M A Elliott, A Tefferi
Mar 23, 2005·Lancet·E Joanna BaxterUNKNOWN Cancer Genome Project
Apr 29, 2005·The New England Journal of Medicine·Robert KralovicsRadek C Skoda
Jul 8, 2005·The New England Journal of Medicine·Claire N HarrisonUNKNOWN United Kingdom Medical Research Council Primary Thrombocythemia 1 Study
Jul 8, 2005·The New England Journal of Medicine·Tiziano Barbui, Guido Finazzi
Oct 4, 2005·British Journal of Haematology·Alexandra P WolanskyjAyalew Tefferi

❮ Previous
Next ❯

Citations

Apr 30, 2010·Analytical and Bioanalytical Chemistry·Jessica K KonstantouJan Traeger-Synodinos
Mar 2, 2012·The New England Journal of Medicine·Claire HarrisonGiovanni Barosi
May 27, 2009·Current Opinion in Hematology·Giovanni Barosi, Vittorio Rosti
Jan 21, 2010·Current Opinion in Hematology·Andrew T Chen, Josef T Prchal
Nov 21, 2013·Molecular Cancer·Miguel GallardoJoaquin Martinez-Lopez
Oct 19, 2010·Acta chirurgica Iugoslavica·Z P CvetkovićG Perunicić-Peković
Feb 24, 2009·Leukemia & Lymphoma·Ayalew Tefferi
Oct 16, 2014·Leukemia & Lymphoma·Chul Won JungKoichi Akashi
Feb 23, 2011·Leukemia & Lymphoma·Martha Q Lacy, Ayalew Tefferi
Dec 5, 2008·Leukemia & Lymphoma·Ayalew Tefferi
Jun 30, 2012·Medicina clínica·Ana Esther Kerguelén FuentesAna Rodriguez de la Rúa
Apr 23, 2011·La Revue de médecine interne·A EsparcieuxD Vital-Durand
Sep 3, 2010·Mayo Clinic Proceedings·Lorraine C Pelosof, David E Gerber
May 22, 2010·Hematology/oncology Clinics of North America·Bruce D AdamsSusan Spencer
Oct 31, 2009·Journal of Vascular and Interventional Radiology : JVIR·Karim Valji, Michael Linenberger
Aug 4, 2009·Emergency Medicine Clinics of North America·Bruce D AdamsSusan Spencer
Sep 5, 2009·American Journal of Hematology·Ayalew Tefferi, Francesco Passamonti
Jan 15, 2009·European Journal of Haematology·Kebede HusseinAyalew Tefferi
Oct 18, 2013·Journal of Cellular and Molecular Medicine·Min Yue ZhangChor Sang Chim
May 9, 2009·American Journal of Hematology·Robert H Cook-NorrisMark D P Davis
Jan 1, 2014·European Journal of Haematology·Odile MoulardRuben A Mesa
Aug 20, 2015·ACS Medicinal Chemistry Letters·Honghe WanAshok V Purandare
Sep 30, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David S SnyderStephen J Forman
Sep 1, 2009·Biochimica Et Biophysica Acta·Yanhong MaYuxun Wang
Dec 22, 2017·JCI Insight·Lindsay Am ReinRobert J Lefkowitz
Apr 1, 2011·Therapeutic Advances in Hematology·Daniel Chan, Maya Koren-Michowitz
Dec 12, 2012·Expert Review of Hematology·Rami Komrokji, Srdan Verstovsek
Oct 12, 2019·Clinical Lymphoma, Myeloma & Leukemia·Odit GutweinMaya Koren-Michowitz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.