'Essential tremor' or 'the essential tremors': is this one disease or a family of diseases?

Neuroepidemiology
Elan D Louis

Abstract

There is accumulating evidence that the entity referred to as 'essential tremor' (ET) is not a single disease. It may be a family of diseases better referred to as 'the ETs'. This review will summarize the following evidence: (1) the presence of etiological heterogeneity; (2) the heterogeneity of findings in postmortem studies, thus suggesting several diseases; (3) the recent discussion that age of onset may be an important marker of disease heterogeneity; (4) the clinical expansion of the concept of ET in recent years to include a broader range of tremor phenomenology, other motor features (gait ataxia), other involuntary movements (dystonia), and nonmotor features (cognitive problems, psychiatric problems), some of which could be primary; (5) the heterogeneity of pharmacological response profiles and clinical progression, and (6) the association of ET with Parkinson's disease, Alzheimer's disease, and possibly progressive supranuclear palsy, with the possibility that some ET patients are more predisposed to develop one of these. © 2013 S. Karger AG, Basel.

Citations

Apr 18, 2014·Current Neurology and Neuroscience Reports·Elan D Louis
Nov 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Hilal Unal GulsunerAyse B Tekinay
Feb 5, 2016·Brain Imaging and Behavior·Diana N KirkeKristina Simonyan
Sep 27, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Weidong FangTianyou Luo
Jan 21, 2016·Journal of Clinical Movement Disorders·Amar Patel, Steven J Frucht
Apr 12, 2015·Revue neurologique·E BoutinT Witjas
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hilal Unal GulsunerAyse B Tekinay
Oct 27, 2015·The Cerebellum·Juan Marin-Lahoz, Alexandre Gironell
Oct 29, 2015·European Journal of Human Genetics : EJHG·Xinmin LiuLorraine N Clark
Sep 4, 2015·PloS One·Jesús de Pedro-CuestaMiguel Calero
Jul 8, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Franziska HopfnerGünther Deuschl
Aug 27, 2016·Revue neurologique·F GövertG Deuschl
May 25, 2015·Revue neurologique·L N Clark, E D Louis
Oct 23, 2016·Parkinsonism & Related Disorders·Franziska HopfnerGünther Deuschl
Jun 6, 2015·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Elan D Louis
Jun 26, 2015·Current Opinion in Neurology·Felix Gövert, Günther Deuschl
Jun 4, 2016·Current Opinion in Neurology·Rodger J Elble
Jul 6, 2019·Practical Neurology·Elan D Louis
Jun 21, 2014·Current Opinion in Neurology·Elan D Louis
Jun 24, 2017·Translational Neurodegeneration·Wei ChenGünther Deuschl
May 30, 2019·Annals of Clinical and Translational Neurology·Yi-Lin OngEng-King Tan
Dec 11, 2019·Brain : a Journal of Neurology·Qi-Ying SunBei-Sha Tang
Jan 22, 2020·Nature Reviews. Neurology·Elan D Louis, Phyllis L Faust
Jul 7, 2017·Cerebellum & Ataxias·Jonathan P DykeElan D Louis
Jul 20, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Anna LatorreJohn C Rothwell
Sep 15, 2020·Cerebellum & Ataxias·Elan D Louis, Phyllis L Faust
Nov 5, 2020·Brain : a Journal of Neurology·Calwing LiaoGuy A Rouleau
Nov 11, 2019·Neuroscience Letters·Regina T MartuscelloPhyllis L Faust
Mar 23, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Elina Tripoliti

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