Essential tremor-the most common movement disorder in older people

Age and Ageing
Bhomraj ThanviTom Robinson

Abstract

Essential tremor (ET) affects approximately 4% of the population above 65 years of age. The traditional view that ET is a familial monosymptomatic disorder with a benign prognosis has recently been challenged, as it is now known to be a progressive and clinically heterogeneous condition with sporadic and familial forms. The pathogenesis of ET is not fully understood, though a disordered central mechanism is the most likely site of origin with possible modulation by muscle adrenoreceptors. The limited post-mortem studies have not shown consistent abnormalities in the brains of ET patients. ET is often misdiagnosed as Parkinson's disease, particularly in the older population. Tremor amplitude increases with age, accounting for substantial disability in older people. Current therapy (drugs and neurosurgery) has significant limitations in older people. A better understanding of its pathophysiology in the future will help in developing more effective therapy, including neuroprotective strategies.

References

Jun 1, 1992·Experimental Neurology·R J ElbleL Hughes
Apr 1, 1992·Clinical Neuropharmacology·W C KollerR Dubinsky
Feb 1, 1991·Neurology·J S Lou, J Jankovic
Feb 1, 1988·Neurology·S J Huber, G W Paulson
Jul 1, 1968·The Journal of Nervous and Mental Disease·H M BlackerP Molina-Negro
Aug 1, 1994·Brain : a Journal of Neurology·P G BainC D Marsden
Aug 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·P G BainC D Marsden
May 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society·J JankovicJ Mordaunt
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·H Boecker, D J Brooks
Aug 6, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·H WilmsG Deuschl
Dec 18, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·E D LouisQ Yu
Aug 15, 2003·Archives of Physical Medicine and Rehabilitation·Martin Grabois
Dec 16, 2003·Movement Disorders : Official Journal of the Movement Disorder Society·Vicky Marshall, Donald Grosset
Mar 24, 2004·Neurology·Alexander RajputAli H Rajput
Mar 1, 2005·Parkinsonism & Related Disorders·Shuhei MoritaTomoyoshi Kondo
May 25, 2005·Neurology·Julián Benito-LeónUNKNOWN Neurological Disorders in Central Spain (NEDICES) Study Group
Jun 16, 2005·Archives of Neurology·Elan D LouisCarol B Moskowitz
Jun 24, 2005·Neurology·T A ZesiewiczUNKNOWN Quality Standards Subcommittee of the American Academy of Neurology
Aug 17, 2005·Parkinsonism & Related Disorders·Alexander I TrösterKelly E Lyons

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Citations

Aug 29, 2014·Surgical Neurology International·Damián BenderskyClaudio Yampolsky
Jun 11, 2008·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Jeannette Y Wick, Guido R Zanni
Feb 16, 2011·Seminars in Neurology·Andreas Puschmann, Zbigniew K Wszolek
Mar 26, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Elan D LouisAmanda S Viner
Feb 23, 2012·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Hatice BalabanSuat Topaktaş
Oct 16, 2012·Artificial Intelligence in Medicine·Vida GroznikIvan Bratko
Jan 3, 2012·Pulmonary Pharmacology & Therapeutics·Mario Cazzola, Maria Gabriella Matera
Nov 21, 2015·Neurobiology of Disease·Joshua J WhiteRoy V Sillitoe
May 17, 2011·Parkinsonism & Related Disorders·Dustin A HeldmanJoseph P Giuffrida
Oct 28, 2006·Human Mutation·Suzanne LesageUNKNOWN French Parkinson Disease Genetics Study Group
Mar 2, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Maira Tonidandel BarbosaFrancisco Cardoso
Jan 14, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E D LouisC Henchcliffe
Sep 26, 2014·Practical Neurology·Khalid Ali, Huw R Morris
Jun 21, 2008·The Annals of Otology, Rhinology, and Laryngology·Gayle Woodson
Mar 31, 2007·Physiological Measurement·Mario MantoStephane Camut
Apr 12, 2019·Disability and Rehabilitation·Jessica MooreJane Simpson
Nov 1, 2012·Journal of Veterinary Emergency and Critical Care·Mark D Haworth, Lisa Smart
Jun 6, 2018·Frontiers in Neuroscience·Bin ZhangDingguo Zhang
Dec 13, 2019·Age and Ageing·Victoria J Haunton
Mar 3, 2020·Expert Review of Neurotherapeutics·Joshua K WongMichael S Okun
Feb 28, 2015·The Veterinary Record·Richard MalikAndy H Sparkes
Dec 11, 2019·Expert Reviews in Molecular Medicine·Hao DengJoseph Jankovic
Apr 1, 2017·Frontiers in Neurology·Xiaochen ZhengYolanda Aladro
May 5, 2020·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Do-Young KwonJi-Won Kim
May 24, 2017·Journal of the American Animal Hospital Association·Corinne LawsonMaureen McMichael
Nov 8, 2011·Journal of the American Animal Hospital Association·Margaret R Slater, Sharon Gwaltney-Brant
Feb 18, 2021·Journal of the American Medical Directors Association·Ryan McGrath

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