Establishing a cohort at high risk of HIV infection in South Africa: challenges and experiences of the CAPRISA 002 acute infection study.

PloS One
Francois van LoggerenbergCAPRISA 002 Acute Infection Study Team

Abstract

To describe the baseline demographic data, clinical characteristics and HIV-incidence rates of a cohort at high risk for HIV infection in South Africa as well as the challenges experienced in establishing and maintaining the cohort. Between August 2004 and May 2005 a cohort of HIV-uninfected women was established for the CAPRISA 002 Acute Infection Study, a natural history study of HIV-1 subtype C infection. Volunteers were identified through peer-outreach. The cohort was followed monthly to determine HIV infection rates and clinical presentation of early HIV infection. Risk reduction counselling and male and female condoms were provided. After screening 775 individuals, a cohort of 245 uninfected high-risk women was established. HIV-prevalence at screening was 59.6% (95% CI: 55.9% to 62.8%) posing a challenge in accruing HIV-uninfected women. The majority of women (78.8%) were self-identified as sex-workers with a median of 2 clients per day. Most women (95%) reported more than one casual sexual partner in the previous 3 months (excluding clients) and 58.8% reported condom use in their last sexual encounter. Based on laboratory testing, 62.0% had a sexually transmitted infection at baseline. During 390 person-years of follow-u...Continue Reading

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Citations

Mar 5, 2014·Nature·Nicole A Doria-RoseJohn R Mascola
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Mar 1, 2012·PloS One·Francois van LoggerenbergUNKNOWN CAPRISA 002 Acute Infection Study Team
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Feb 26, 2015·The Journal of Infectious Diseases·Oliver LaeyendeckerThomas C Quinn

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Methods Mentioned

BETA
blood
urine collection
blood collection
PCR

Software Mentioned

CAPRISA
SAS

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