Establishing a Core Outcome Measure for Graft Health: A Standardized Outcomes in Nephrology-Kidney Transplantation (SONG-Tx) Consensus Workshop Report

Transplantation
Allison TongSONG-Tx Graft Health Workshop Investigators

Abstract

Graft loss, a critically important outcome for transplant recipients, is variably defined and measured, and incompletely reported in trials. We convened a consensus workshop on establishing a core outcome measure for graft loss for all trials in kidney transplantation. Twenty-five kidney transplant recipients/caregivers and 33 health professionals from 8 countries participated. Transcripts were analyzed thematically. Five themes were identified. "Graft loss as a continuum" conceptualizes graft loss as a process, but requiring an endpoint defined as a discrete event. In "defining an event with precision and accuracy," loss of graft function requiring chronic dialysis (minimum, 90 days) provided an objective and practical definition; retransplant would capture preemptive transplantation; relisting was readily measured but would overestimate graft loss; and allograft nephrectomy was redundant in being preceded by dialysis. However, the thresholds for renal replacement therapy varied. Conservative management was regarded as too ambiguous and complex to use routinely. "Distinguishing death-censored graft loss" would ensure clarity and meaningfulness in interpreting results. "Consistent reporting for decision making" by specifying ti...Continue Reading

References

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Citations

Jan 1, 2020·Clinical Transplantation·Mark D StegallCarrie Schinstock
Dec 10, 2019·Current Opinion in Organ Transplantation·Umberto MaggiorePaolo Cravedi
Mar 1, 2020·BMJ Open·Noel EngelsAnne M Stiggelbout
Aug 29, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Samuel ChanDavid W Johnson
Aug 18, 2020·The Cochrane Database of Systematic Reviews·Samuel ChanDavid W Johnson
Feb 25, 2020·Transplantation·Elisabet Van LoonMaarten Naesens
Feb 28, 2021·Kidney International·UNKNOWN Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group
Mar 25, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Hassan N IbrahimGreg A Knoll
Aug 6, 2020·Néphrologie & thérapeutique·Carole AyavUNKNOWN Commission épidémiologie et santé publique de la Société francophone de néphrologie, dialyse et transplantation

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