Establishing a Reproducible Hypertrophic Scar following Thermal Injury: A Porcine Model

Plastic and Reconstructive Surgery. Global Open
Scott J RappBrian S Pan

Abstract

Our complete understanding of hypertrophic scarring is still deficient, as portrayed by the poor clinical outcomes when treating them. To address the need for alternative treatment strategies, we assess the swine animal burn model as an initial approach for immature scar evaluation and therapeutic application. Thermal contact burns were created on the dorsum of 3 domestic swine with the use of a branding iron at 170°F for 20 seconds. Deep partial-thickness burns were cared for with absorptive dressings over 10 weeks and wounds evaluated with laser and negative pressure transduction, histology, photographic analysis, and RNA isolation. Overall average stiffness (mm Hg/mm) increased and elasticity (mm) decreased in the scars from the initial burn injury to 8 weeks when compared with normal skin (P < 0.01). Scars were thicker, more erythematous, and uniform in the caudal dorsum. The percent change of erythema in wounds increased from weeks 6 to 10. Histology demonstrated loss of dermal papillae, increased myofibroblast presence, vertically oriented vessels, epidermal and dermal hypercellularity, and parallel-layered collagen deposition. Immature scars remained elevated at 10 weeks, and minimal RNA was able to be isolated from the ...Continue Reading

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Citations

Feb 12, 2017·Burns : Journal of the International Society for Burn Injuries·Mehmet Surhan ArdaCengiz Çetin
Dec 22, 2017·Plastic and Reconstructive Surgery. Global Open·Scott J RappBrian S Pan
Mar 13, 2021·International Journal of Experimental Pathology·Wenxuan ZuHongwei Liu
May 4, 2021·Burns : Journal of the International Society for Burn Injuries·Hanna LuzeLars-Peter Kamolz

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