Establishing age-associated normative ranges of the cerebral 18F-FDG uptake ratio in children

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Chiaho HuaBarry L Shulkin

Abstract

In this study, we reported age-associated ranges of the regional cerebral (18)F-FDG uptake ratio in pediatric patients as a surrogate to normative data from healthy children. (18)F-FDG PET scans of 132 children and adolescents (age, 1-20 y) with non-central nervous system-related diseases and normal-appearing tracer distributions in the brain were retrospectively analyzed. PET images of individual patients were warped to a 3-dimensional reference template. Uptake ratio was calculated for 63 anatomic regions by normalizing the regional count per voxel with the average count per voxel in all regions. Models of regional uptake ratio as a function of age and sex were developed to calculate the 95% prediction interval. The paracentral lobule and cuneus had the highest resting metabolic state among all gray matter regions, whereas the brain stem, uncus, and hippocampus had the lowest uptake. A large left-right asymmetry was present in the angular gyrus and inferior occipital gyrus. Quantitative data of the regression, 95% confidence interval, and 95% prediction interval for each age were summarized for the 63 regions. In 52 of 63 regions, the (18)F-FDG uptake ratio had a significant age effect. The linear model was optimal for 12 reg...Continue Reading

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Citations

Sep 11, 2018·Nuclear Medicine Communications·Thomas W BarberPeter Francis
Sep 15, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Qi HuangJianhua Yan
Apr 10, 2020·Journal of Religion and Health·Rachel S WerkAndrew Newberg
Mar 8, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Martina SolliniArturo Chiti
May 28, 2019·Seizure : the Journal of the British Epilepsy Association·Csaba Juhász, Flóra John
Dec 30, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sophie TurpinRaymond Lambert
Apr 8, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bianca De BlasiMartin Tisdall

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