Establishing an in vivo model of canine prostate carcinoma using the new cell line CT1258.

BMC Cancer
Melani A M ForkIngo Nolte

Abstract

Prostate cancer is a frequent finding in man. In dogs, malignant disease of the prostate is also of clinical relevance, although it is a less common diagnosis. Even though there are numerous differences in origin and development of the disease, man and dog share many similarities in the pathological presentation. For this reason, the dog might be a useful animal model for prostate malignancies in man.Although prostate cancer is of great importance in veterinary medicine as well as in comparative medicine, there are only few cell lines available. Thus, it was the aim of the present study to determine whether the formerly established prostate carcinoma cell line CT1258 is a suitable tool for in vivo testing, and to distinguish the growth pattern of the induced tumours. For characterisation of the in vivo behaviour of the in vitro established canine prostate carcinoma cell line CT1258, cells were inoculated in 19 NOD.CB17-PrkdcScid/J (in the following: NOD-Scid) mice, either subcutaneously or intraperitoneally. After sacrifice, the obtained specimens were examined histologically and compared to the pattern of the original tumour in the donor. Cytogenetic investigation was performed. The cell line CT 1258 not only showed to be high...Continue Reading

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Citations

Jun 11, 2014·PloS One·Saskia WillenbrockHugo Murua Escobar
Jul 3, 2015·International Journal of Oncology·Yong-Qi CuiMing-Xia Yan
Jul 22, 2014·The Prostate·Jessica K SimmonsThomas J Rosol
Jan 22, 2013·The Prostate·Jill M KellerEvan T Keller
Apr 30, 2020·The Prostate·Said M ElshafaeThomas J Rosol
Jul 3, 2020·Alternatives to Laboratory Animals : ATLA·Elisabete Nascimento-GonçalvesBruno Jorge Antunes Colaço
Nov 11, 2019·International Journal of Molecular Sciences·Jan Torben SchilleHugo Murua Escobar
Feb 9, 2021·Frontiers in Veterinary Science·Jan Torben SchilleHugo Murua Escobar

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Methods Mentioned

BETA
biopsies
FCS
dissection
xenograft

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