Establishing an intracytoplasmic sperm injection (ICSI) programme for the treatment of male factor infertility in Ireland

Irish Journal of Medical Science
A C GordonM Fawzy

Abstract

This paper chronicles the introduction and initial experiences of Intra Cytoplasmic Sperm Injection (ICSI) as a treatment for severe male factor infertility in Ireland. Following initial development of the technique using a bovine model, therapy was offered clinically from September 1995. Up to March 1996 a total of 60 couples underwent the procedure. Fertilisation and embryo transfers were achieved in 50 of these (83.3 percent). Fourteen (23 percent) became clinically pregnant per cycle commenced, 28 percent per embryo transfer. Despite a drop in the total number of oocytes available, fertilisation rates rose over the 6 months of the study from 22 percent to 54 percent. There were 2 miscarriages (14.2 percent) and the multiple pregnancy rate was 28.5 percent. Eight singletons, 2 twins and 2 triplet sets have been successfully delivered. Provided there is proper patient selection, ICSI should prove a valuable addition to treatment options available to infertile couples in Ireland.

References

Jul 1, 1992·Fertility and Sterility·I Ben-ShlomoZ Ben-Rafael
Jul 1, 1993·Human Reproduction·A C Van SteirteghemP Devroey
Feb 1, 1993·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y Ezra, J G Schenker
Jul 1, 1995·Human Reproduction·I Craft, M Tsirigotis
Oct 1, 1995·Human Reproduction·J M Cummins, A M Jequier

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Citations

Jun 10, 2000·Irish Journal of Medical Science·S JacobR F Harrison
Sep 23, 2000·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M DirnfeldD Bider
Dec 14, 2011·Human Fertility : Journal of the British Fertility Society·Robert F Harrison

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