Establishing an osteoimmunomodulatory coating loaded with aspirin on the surface of titanium primed with phase-transited lysozyme

International Journal of Nanomedicine
Wenxin ZhangXu Zhang

Abstract

To improve osseointegration and enhance the success rate of implanted biomaterials, the surface modification technology of bone implants has developed rapidly. Intensive research on osteoimmunomodulation has shown that the surfaces of implants should possess favorable osteoimmunomodulation to facilitate osteogenesis. A novel, green and efficient phase-transited lysozyme (PTL) technique was used to prime titanium discs with a positive charge. In addition, sodium hyaluronate (HA) and self-assembled type I collagen containing aspirin (ASA) nanoparticles were decorated on PTL-primed Ti discs via electrostatic interaction. The behaviors of bone marrow stromal cells (BMSCs) on the Ti disc surfaces containing ASA were analyzed in different conditioned media (CM) generated by macrophages. Additionally, the secretion of inflammation-related cytokines of macrophages on the surfaces of different Ti discs was investigated in in vitro experiments, which showed that the Ti surface containing ASA not only supported the migration, proliferation and differentiation of BMSCs but also reduced the inflammatory response of macrophages compared with Ti discs without surface modification. After implantation in vivo, the ASA-modified implant can signi...Continue Reading

Citations

Sep 29, 2020·International Journal of Nanomedicine·Li ZhangFrank A Schildberg
Jan 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min HeWeidong Tian
Feb 23, 2020·International Journal of Biological Macromolecules·Sharanya SarkarKrishna Mohan Poluri
Jun 18, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Min HeWeidong Tian
Jul 6, 2021·Stem Cells International·Rita Lih-Ying ShinOscar Kuang-Sheng Lee

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Methods Mentioned

BETA
transmission electron microscopy
scanning electron microscopy
protein assay
ELISA
PCR

Software Mentioned

Pro Plus
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