Establishing and maintaining cell polarity with mRNA localization in Drosophila

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Justinn BarrP Schedl

Abstract

How cell polarity is established and maintained is an important question in diverse biological contexts. Molecular mechanisms used to localize polarity proteins to distinct domains are likely context-dependent and provide a feedback loop in order to maintain polarity. One such mechanism is the localized translation of mRNAs encoding polarity proteins, which will be the focus of this review and may play a more important role in the establishment and maintenance of polarity than is currently known. Localized translation of mRNAs encoding polarity proteins can be used to establish polarity in response to an external signal, and to maintain polarity by local production of polarity determinants. The importance of this mechanism is illustrated by recent findings, including orb2-dependent localized translation of aPKC mRNA at the apical end of elongating spermatid tails in the Drosophila testis, and the apical localization of stardust A mRNA in Drosophila follicle and embryonic epithelia.

References

Oct 16, 1992·Cell·E R Gavis, R Lehmann
Jun 1, 1993·Molecular and Cellular Biology·D DingH D Lipshitz
Mar 1, 1994·Genes & Development·L B Christerson, D M McKearin
Jun 1, 1993·The Journal of Cell Biology·S N Hird, J G White
Jan 1, 1997·Annual Review of Genetics·M de CuevasA C Spradling
Jun 1, 2000·Cell·K Kemphues
Apr 3, 2001·Nature Reviews. Molecular Cell Biology·R P Jansen
Nov 9, 2001·Annual Review of Genetics·U TepassR Fehon
Feb 20, 2003·Mechanisms of Development·Paolo Filardo, Anne Ephrussi
Apr 16, 2004·Current Biology : CB·Jonathan B HurovHelen Piwnica-Worms
Apr 27, 2005·Nature Reviews. Molecular Cell Biology·Daniel St Johnston

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Citations

Jul 12, 2018·Cell Cycle·Zaur M KachaevYulii V Shidlovskii
Feb 9, 2021·PLoS Computational Biology·Rocky DiegmillerKonstantin Mischaikow
Oct 12, 2021·Cellular and Molecular Life Sciences : CMLS·Shekoufeh Almasi, Bernard J Jasmin

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