PMID: 6775685Sep 1, 1980Paper

Establishing full-term human pregnancies using cleaving embryos grown in vitro

British Journal of Obstetrics and Gynaecology
R G EdwardsJ M Purdy

Abstract

The establishment of human pregnancies by the use of fertilization in vitro and placing cleaving embryos into the uterus is described. Preovulatory oocytes were aspirated at laparoscopy from the ovaries of patients soon after the beginning of the mid-cycle surge of luteinizing hormone (LH) during the natural cycle. The LH surge was identified by assaying 3-hourly samples of urine, and measurements of oestrogens in 24-hour samples were used to assess follicular growth. The surge of LH was identified in 68 patients and it showed a diurnal rhythm. Preovulatory oocytes were aspirated from most of the patients. Fertilization and cleavage occurred in 34 instances, and 32 embryos were put into the mother via the cervical canal. Four patients became pregnant. There were indications that a diurnal rhythm played a role in establishing cleaving embryos, each of the four pregnancies occurring when the embryos were placed in late evening. Each of the pregnancies resulted from oocytes which were aspirated from their follicles 24 hours or longer after the LH surge began. Details are given of three abortive pregnancies in patients given gonadotrophins to stimulate the maturation of of oocytes used for fertilization in vitro.

References

Aug 1, 1979·British Journal of Industrial Medicine·E Grandjean
Apr 24, 1976·Lancet·P C Steptoe, R G Edwards
Jan 1, 1979·Journal of Reproduction and Fertility·M F HayH M Dott
Jul 1, 1978·Theriogenology·J M BowenG E Seidel
Mar 1, 1977·British Journal of Obstetrics and Gynaecology·M CampograndeM Brizzolara
Jan 1, 1976·Journal of Supramolecular Structure·T L SteckA R Tarlov
Aug 1, 1974·The Journal of Clinical Endocrinology and Metabolism·H G SpiesJ A Resko
Apr 1, 1974·Journal of Reproduction and Fertility·L Marsk, K S Larsson
Jan 8, 1971·Nature·P C SteptoeJ M Purdy
Oct 8, 1971·Nature·L E Rowson
Jul 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Rogers, J Chamberlain
Sep 1, 1980·British Journal of Obstetrics and Gynaecology·P C SteptoeJ M Purdy
Sep 1, 1980·British Journal of Obstetrics and Gynaecology·R G EdwardsJ Baillie

Citations

Mar 10, 1998·Molecular Reproduction and Development·A R GreenleeE D Plotka
Apr 1, 1986·Human Genetics·R AngellR J Aitken
Mar 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·R G EdwardsJ Webster
Mar 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·A Trounson, C Wood
Mar 1, 1985·Journal of in Vitro Fertilization and Embryo Transfer : IVF·L R MohrL Freemann
Jun 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·B A DidionE J Eisen
Feb 1, 1990·Journal of in Vitro Fertilization and Embryo Transfer : IVF·N HolstH I Nielsen
Apr 1, 1990·Journal of in Vitro Fertilization and Embryo Transfer : IVF·S Nader, A S Berkowitz
Sep 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·T C Appleton, S B Fishel
Jun 1, 1985·Journal of in Vitro Fertilization and Embryo Transfer : IVF·J CohenS B Fishel
Apr 1, 1986·Journal of in Vitro Fertilization and Embryo Transfer : IVF·W FeichtingerY Menezo
May 1, 1993·Journal of Assisted Reproduction and Genetics·D C LoutradisD Aravantinos
Aug 1, 1993·Journal of Assisted Reproduction and Genetics·S FriedlerJ G Schenker
Feb 1, 1987·Journal of in Vitro Fertilization and Embryo Transfer : IVF·G A HillA C Wentz
Apr 1, 1995·Journal of Assisted Reproduction and Genetics·T Levy, Z Ben-Rafael
Mar 1, 1994·Journal of Assisted Reproduction and Genetics·H F ChenY S Yang
Apr 10, 2009·Archives of Gynecology and Obstetrics·Razieh Dehghani FirouzabadiRobab Davar
Apr 1, 1988·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·A ChryssikopoulosE Vazoura
Feb 1, 1984·Journal of Steroid Biochemistry·R FrydmanM Roger
Jan 10, 1988·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·N HolstJ M Maltau
Oct 16, 2013·Reproductive Biomedicine Online·A Trounson
Apr 9, 1998·Fertility and Sterility·K SharifL Sinclair
Oct 31, 1998·Fertility and Sterility·M H ThorntonR J Paulson
Nov 21, 1981·Lancet·M J KilpatrickW P Collins
Nov 21, 1981·Lancet·I CraftH Twigg
Dec 5, 1981·Lancet·H G BohnetF A Leidenberger
Jun 14, 2002·Journal of Reproductive Immunology·A TavaniotouP Devroey
Mar 22, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mona M AboulgharAhmed M Abou-Setta
Jun 27, 2003·Trends in Endocrinology and Metabolism : TEM·Bart C Fauser, P Devroey
Mar 3, 2004·Reproductive Biomedicine Online·Ri-Cheng ChianSeang-Lin Tan
Jun 1, 2005·Reproductive Biomedicine Online·Christoph Dorn, Hans van der Ven
Nov 6, 2004·Journal of Assisted Reproduction and Genetics·Peter KovacsSteven G Kaali
Dec 17, 2009·Human Reproduction·Jan Gerris, Petra De Sutter
Apr 20, 2011·Human Reproduction·Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology
Jul 4, 2012·Human Reproduction·Fernando J PradosInge Agerholm
Apr 1, 2011·Human Reproduction Update·Peter HumaidanCopenhagen GnRH Agonist Triggering Workshop Group
Oct 12, 2013·Molecular Human Reproduction·Stephen G Hillier
Apr 30, 2004·Pharmacogenetics·Francisco de CastroAgustín Ruiz
May 5, 2005·Current Opinion in Obstetrics & Gynecology·Recai Pabuccu, Munire Erman Akar
Aug 1, 1995·The Journal of Obstetrics and Gynaecology·M A AboulgharA M Ramzy
Jul 24, 1982·British Medical Journal·A Trounson, A Conti
Dec 2, 1989·BMJ : British Medical Journal·P R Braude, M Johnson
Nov 18, 2003·Reproductive Biology and Endocrinology : RB&E·Ralf R Henkel, Wolf-Bernhard Schill
Feb 10, 2012·Development·Kathy K NiakanRenee A Reijo Pera
Oct 1, 1987·Environmental Health Perspectives·S R GlasserM J Soares
Mar 25, 2008·Therapeutics and Clinical Risk Management·Jeff Wang, Mark V Sauer
Jun 1, 1996·Journal of Endocrinological Investigation·A Cagnacci, A Volpe
Dec 21, 2013·Archives of Gynecology and Obstetrics·Sabine RoesnerBettina Toth
Mar 22, 2014·Journal of Assisted Reproduction and Genetics·Francesca E DuncanTeresa K Woodruff
Sep 28, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S Zalányi
Jul 17, 2007·Journal of Assisted Reproduction and Genetics·Martin WildingBrian Dale
Aug 19, 2014·BioMed Research International·Juan Carlos CastilloRafael Bernabéu
Jul 19, 2014·Human Reproduction Update·Elpiniki Chronopoulou, Joyce C Harper
May 17, 2013·Human Fertility : Journal of the British Fertility Society·Eli Y Adashi, Howard W Jones
Sep 24, 2015·Human Fertility : Journal of the British Fertility Society·Stephen HarbottleAssociation Of Clinical Embryologists & The (ACE) British Fertility Society (BFS)
Dec 13, 2002·Human Fertility : Journal of the British Fertility Society·Laurence M A ShawCHILD, National Infertility Support Network
Dec 13, 2002·Human Fertility : Journal of the British Fertility Society·Lynette Scott
Mar 1, 1986·American Journal of Obstetrics and Gynecology·R FrydmanJ Testart
Jan 1, 1984·American Journal of Obstetrics and Gynecology·S SuzukiR Iizuka
Dec 15, 1985·American Journal of Obstetrics and Gynecology·A H DecherneyN Laufer
Mar 29, 2011·Gynécologie, obstétrique & fertilité·S SalamaR Wainer
Jan 23, 2003·Reproductive Biomedicine Online·M H van der GaastBart C Fauser
Jan 9, 2016·Nature Biotechnology·Yaojin Peng
Mar 2, 2012·Reproductive Biomedicine Online·Nathalie SermondadeJacqueline Mandelbaum
Dec 27, 2011·Reproductive Biomedicine Online·Peter HumaidanH M Fatemi
Jun 14, 2005·Reproductive Biomedicine Online·Laura RienziErmanno Greco
Feb 6, 2010·Reproductive Biomedicine Online·H M Fatemi
Jan 7, 2003·Reproductive Biomedicine Online·Veronica AlamFrancisco Rísquez
Jun 21, 2007·Reproductive Biomedicine Online·Veljko Vlaisavljevic
Oct 31, 2015·Placenta·Chunfang QiuMichelle A Williams
Mar 8, 2008·Fertility and Sterility·Pasquale Patrizio, Denny Sakkas
Mar 6, 2007·Gynécologie, obstétrique & fertilité·L ReyftmannB Hédon
Sep 9, 2015·Acta Obstetricia Et Gynecologica Scandinavica·Walter Ciampaglia, Graciela E Cognigni
Nov 4, 2004·BJOG : an International Journal of Obstetrics and Gynaecology·Zouhair O Amarin, Basil R Obeidat
Mar 18, 2016·Human Fertility : Journal of the British Fertility Society·Laurentiu Craciunas, Nikolaos Tsampras
Jan 19, 2010·Australian and New Zealand Journal of Public Health·Danielle L HerbertAnnette J Dobson
Jul 25, 2015·Journal of Assisted Reproduction and Genetics·Clara J MenCatherine Racowsky
Feb 4, 1999·Baillière's Clinical Obstetrics and Gynaecology·T J Child, D H Barlow
Mar 1, 1991·Baillière's Clinical Obstetrics and Gynaecology·J Yovich, A Lower
Feb 1, 1982·Clinical Endocrinology·R Fleming, J R Coutts
Feb 1, 1995·American Journal of Obstetrics and Gynecology·R C StricklerD B Williams
Mar 17, 2015·Journal of Assisted Reproduction and Genetics·Ronit MachtingerCatherine Racowsky
Jan 25, 2014·Reproductive Biomedicine Online·L DerksenChristophe Blockeel
Dec 14, 2011·Fertility and Sterility·Peter Humaidan
Jul 26, 2011·Fertility and Sterility·Stefan SchanzGerhard Fierlbeck
Feb 16, 2015·Obstetrics and Gynecology Clinics of North America·Tolga B Mesen, Steven L Young
Jul 21, 2016·Human Fertility : Journal of the British Fertility Society·Wael A Ismail MadkourAshraf Moawad
Oct 11, 2016·Journal of Assisted Reproduction and Genetics·Alexander M Quaas, Karl R Hansen
Jun 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·E A LentonS Verma
Jul 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·C J Crace
Oct 9, 2001·Nature Medicine·R G Edwards
Jul 8, 2015·The Cochrane Database of Systematic Reviews·Michelle van der LindenMostafa Metwally
Sep 28, 2001·Nature·R G Edwards
Sep 24, 1981·Nature·R G Edwards
Jan 1, 1991·Annals of the New York Academy of Sciences·M B DoyleA H Decherney
Jan 1, 1985·Annals of the New York Academy of Sciences·E RudakB Goldman
Feb 4, 2005·Human Reproduction·George B IngeKay T Elder
May 1, 1984·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J L YovichA I Tuvik
Aug 1, 1981·The Australian & New Zealand Journal of Obstetrics & Gynaecology·R P Jansen
Apr 1, 1987·British Journal of Obstetrics and Gynaecology·I E MessinisD T Baird
Feb 1, 1984·British Journal of Obstetrics and Gynaecology·A TempletonD T Baird
Oct 1, 1981·British Journal of Obstetrics and Gynaecology·O DjahanbakhchA A Templeton
Sep 1, 1980·British Journal of Obstetrics and Gynaecology·R G EdwardsJ Baillie
Sep 1, 1987·British Journal of Obstetrics and Gynaecology·D A ImoedemheM Inglis
Jan 26, 2006·Endocrine Reviews·Nick S MacklonBart C Fauser
Apr 12, 2006·Human Reproduction·G A Clarke
Jan 1, 1988·Annals of the New York Academy of Sciences·W FeichtingerP Kemeter
Aug 1, 1985·The Australian & New Zealand Journal of Obstetrics & Gynaecology·P C HoL C Tang
May 1, 1984·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J LeetonC Wood
Jan 1, 1984·Archives of Andrology·H H RiedelL Mettler
Sep 1, 2013·Expert Review of Endocrinology & Metabolism·Jerome H Check, Rachael Cohen
Mar 17, 2005·The Journal of Pharmacology and Experimental Therapeutics·Eve C FeinbergWilliam H Catherino
Jan 23, 2020·Human Reproduction·Lan N VuongPeter Humaidan
Aug 4, 1988·The New England Journal of Medicine·R P JansenP D Sutherland
Sep 3, 2020·Journal of Assisted Reproduction and Genetics·K LattesR Vassena
May 1, 2001·Acta Obstetricia Et Gynecologica Scandinavica·M Ludwig, K Diedrich
Sep 15, 2019·Archives of Gynecology and Obstetrics·Mauro CozzolinoEcem Esencan
Sep 20, 2020·Human Reproduction·Zion Ben Rafael
Jun 1, 1987·Asia-Oceania Journal of Obstetrics and Gynaecology·C M Lim
Nov 1, 1984·The Australian & New Zealand Journal of Obstetrics & Gynaecology·P J Paterson
Aug 4, 2005·Human Reproduction Update·Bart C Fauser, Robert G Edwards
Sep 16, 2018·Journal of Assisted Reproduction and Genetics·David F Albertini
Apr 1, 1983·Developmental Medicine and Child Neurology·R L BruceJ M Purdy
Nov 15, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·I Bar-HavaR Orvieto
Dec 16, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·John Leeton
Jul 13, 2007·Human Reproduction Update·H M FatemiP Devroey
Mar 27, 2015·Current Opinion in Obstetrics & Gynecology·Lise Thomsen, Peter Humaidan
Mar 1, 1990·Journal of Endocrinological Investigation·G B MelisP Fioretti
May 1, 1984·British Journal of Obstetrics and Gynaecology·P SundströmP Liedholm
Mar 1, 1983·Asia-Oceania Journal of Obstetrics and Gynaecology·Y Iwasa, K Yanagino
Feb 24, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S J Fasouliotis, J G Schenker
May 10, 2006·Journal of Human Genetics·Hisashi SatoKazuo Sengoku
Jan 1, 1985·Annals of the New York Academy of Sciences·C M BaylyA L Speirs
Sep 1, 1980·British Journal of Obstetrics and Gynaecology·P C SteptoeJ M Purdy
Jan 1, 1985·Annals of the New York Academy of Sciences·M J GronowJ B Brown
Jun 30, 2000·Human Reproduction·O E ClaassensK L Harrison
Jan 1, 1988·Annals of the New York Academy of Sciences·W FeichtingerP Kemeter
Aug 15, 2020·Journal of Human Reproductive Sciences·Salvatore RaimondoFelice Cuomo
Dec 21, 2017·Reproductive Medicine and Biology·Tatsuma Yao, Yuta Asayama
Oct 6, 2020·Frontiers in Endocrinology·Federica Di GuardoChristophe Blockeel
Oct 12, 2001·Annals of the New York Academy of Sciences·A TavaniotouP Devroey
Aug 20, 1990·The Medical Journal of Australia·R P JansenE Ciancaglini
Feb 21, 2021·Hormone Molecular Biology and Clinical Investigation·Nathalie F WangSven O Skouby
Apr 11, 2020·The Urologic Clinics of North America·Brent M HansonJason M Franasiak
Mar 23, 2021·Fertility and Sterility·Pietro Bortoletto, Phillip A Romanski
May 10, 2021·Journal of Assisted Reproduction and Genetics·Alexander M Quaas

Related Concepts

Circadian Rhythms
Cleavage Stage, Ovum
Blastocyst Transfer
Fertilization in Vitro
Pregnyl
Hormones
Luteozyman
HMG Lepori
Menstruation
Oocytes

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.