Establishing full-term human pregnancies using cleaving embryos grown in vitro
The establishment of human pregnancies by the use of fertilization in vitro and placing cleaving embryos into the uterus is described. Preovulatory oocytes were aspirated at laparoscopy from the ovaries of patients soon after the beginning of the mid-cycle surge of luteinizing hormone (LH) during the natural cycle. The LH surge was identified by assaying 3-hourly samples of urine, and measurements of oestrogens in 24-hour samples were used to assess follicular growth. The surge of LH was identified in 68 patients and it showed a diurnal rhythm. Preovulatory oocytes were aspirated from most of the patients. Fertilization and cleavage occurred in 34 instances, and 32 embryos were put into the mother via the cervical canal. Four patients became pregnant. There were indications that a diurnal rhythm played a role in establishing cleaving embryos, each of the four pregnancies occurring when the embryos were placed in late evening. Each of the pregnancies resulted from oocytes which were aspirated from their follicles 24 hours or longer after the LH surge began. Details are given of three abortive pregnancies in patients given gonadotrophins to stimulate the maturation of of oocytes used for fertilization in vitro.
Steroidogenesis in preovulatory follicles of patients given human menopausal and chorionic gonadotrophins as judged by the radioimmunoassay of steroids in follicular fluid
The effect of human chorionic gonadotropin and estradiol-17beta on the maintenance of the human corpus luteum of early pregnancy
Immunoreactive alpha- and beta-subunits of luteinizing hormone in human peripheral blood and follicular fluid throughout the menstrual cycle, and their effect on the secretion rate of progesterone by human granulosa cells in tissue culture
The use of the steroid analyser in conjunction with a semi-automatic gas chromatograph in the routine analysis of urinary pregnanediol
Plasma levels of progesterone during the luteal phase in normal women treated with synthetic oestrogens (RS 2874, F 6103 and ethinyloestradiol)
Maturity and fertility of rhesus monkey oocytes collected at different intervals after an ovulatory stimulus (human chorionic gonadotropin) in in vitro fertilization cycles
Rapid sexing of murine preimplantation embryos using a nested, multiplex polymerase chain reaction (PCR)
In vitro fertilization results, 1979-1982, at Monash University, Queen Victoria, and Epworth Medical Centres
Preliminary experience with a combination of clomiphene and variable dosages of menopausal gonadotropins for enhanced follicular recruitment
Implantation, abortion, and birth after in vitro fertilization using the natural menstrual cycle or follicular stimulation with clomiphene citrate and human menopausal gonadotropin
Use of in vitro fertilization and embryo transfer to circumvent infertility caused by an inherited imperforate vagina in mice
Optimization and simplification of culture conditions in human in vitro fertilization (IVF) and preembryo replacement by serum-free media
Morphology and X-ray microprobe analysis of spermatozoa from fertile and infertile men in in vitro fertilization
The use of synthetic culture medium and patient serum for human in vitro fertilization and embryo replacement
Combination clomiphene citrate/human menopausal gonadotropin stimulation protocols for in vitro fertilization-embryo transfer
Multiple pregnancies in gonadotropin-stimulated cycles after human in vitro fertilization (IVF) and embryo replacement
Luteal phase following oocyte aspiration, in vitro fertilization, and embryo transfer in clomid/HCG-stimulated cycles
Hormonal and ultrasonic characteristics of 23 clomiphene citrate stimulated cycles resulting in pregnancies after in vitro fertilization and embryo transfer
Experiences with the first 100 consecutive pregnancies achieved after in vitro fertilization and embryo transfer at the University Women's Hospital in Erlangen
Selective capacity of glass-wool filtration for the separation of human spermatozoa with condensed chromatin: a possible therapeutic modality for male-factor cases?
Low- versus high-dose human menopausal gonadotropin in an in vitro fertilization-embryo transfer program
Peptides extracted from Vero cell cultures overcome the blastocyst block of mouse embryos in a serum-free medium
The influence of different amounts of clomiphene citrate on follicle-stimulating hormone, luteinizing hormone and estradiol levels and on the number and maturation of follicles
Mood state as a predictor of treatment outcome after in vitro fertilization/embryo transfer technology (IVF/ET)
The behaviour of LH, FSH, PRL, T, P, estradiol and cortisol under different kinds of general anesthesias during laparoscopic oocyte recovery for in vitro fertilization
Effects of oocyte exposure to local anesthetics on in vitro fertilization and embryo development in the mouse
Value of the serum estradiol level on the day of human chorionic gonadotropin injection and on the day after in predicting the outcome in natural in vitro fertilization/intracytoplasmic sperm injection cycles
Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone
Comparison of transmyometrial and transcervical embryo transfer in patients with previously failed in vitro fertilization-embryo transfer cycles and/or cervical stenosis
Slow decline of plasma drug and prolactin levels after discontinuation of chronic treatment with depot neuroleptics
Comparison of clinical outcome and costs with CC + gonadotropins and gnrha + gonadotropins during Ivf/ICSI cycles
A single nucleotide polymorphism in SPATA17 may be a genetic risk factor for Japanese patients with meiotic arrest
GnRH agonist ovulation trigger and hCG-based, progesterone-free luteal support: a proof of concept study
Reproductive potential of a metaphase II oocyte retrieved after ovarian stimulation: an analysis of 23 354 ICSI cycles
Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS)
Pregnancy established in an infertile patient after transfer of a donated embryo fertilised in vitro
Human sperm bioassay for reprotoxicity testing in embryo culture media: some practical considerations in reducing the assay time
Assisted Reproductive Technologies (ART) with baboons generate live offspring: a nonhuman primate model for ART and reproductive sciences
Serum estradiol/progesterone ratio on day of embryo transfer may predict reproductive outcome following controlled ovarian hyperstimulation and in vitro fertilization
Duration of luteal support (DOLS) with progesterone pessaries to improve the success rates in assisted conception: study protocol for a randomized controlled trial
In vitro fertilization (IVF): a review of 3 decades of clinical innovation and technological advancement
A small field for fertile science: the low visibility of reproductive science in high impact journals
Addition of estradiol to progesterone for luteal supplementation in patients stimulated with GnRH antagonist/rFSH for IVF: a randomized controlled trial
Effect of oocyte quality and sperm characteristics on the number of spermatozoa bound to the zona pellucida of human oocytes inseminated in vitro
Luteal phase support with GnRH-a improves implantation and pregnancy rates in IVF cycles with endometrium of <or=7 mm on day of egg retrieval
National Health Service provision for the management of infertility: the case for funding and reorganization of fertility services in the UK
Embryological strategies for overcoming recurrent assisted reproductive technology treatment failure
Duration of luteal support after IVF is important, so why is there no consistency in practice? The results of a dynamic survey of practice in the United Kingdom
An obstetric assessment of the first 100 births from the in vitro fertilization program at Clamart, France
Progesterone support in IVF: is evidence-based medicine translated to clinical practice? A worldwide web-based survey
Characterization of a recurrent poor-quality embryo morphology phenotype and zygote transfer as a rescue strategy
Use of primate folliculogenesis models in understanding human reproductive biology and applicability to toxicology
Double-quality control reveals high-level toxicity in gloves used for operator protection in assisted reproductive technology
Bed rest following embryo transfer might negatively affect the outcome of IVF/ICSI: a systematic review and meta-analysis
Infertility in Australia circa 1980: an historical population perspective on the uptake of fertility treatment by Australian women born in 1946-51
Vaginal perforation during transvaginal ultrasound-guided follicle aspiration in a woman undergoing multiple cycles of assisted reproduction
Is the presence of an uncleaved embryo on day 3 a useful predictor of outcomes following day 5 transfer?
Endogenous luteinizing hormone surge in women during induction of multiple follicular development with pulsatile follicle stimulating hormone
Daily low-dose hCG stimulation during the luteal phase combined with GnRHa triggered IVF cycles without exogenous progesterone: a proof of concept trial
Pregnancy after in vitro fertilization-intracytoplasmic sperm injection obtained with a modified natural cycle in a BRCA1 mutation carrier
Is the presence of a non-cleaved embryo on day 3 associated with poorer quality of the remaining embryos in the cohort?
Luteal-phase support in assisted reproduction treatment: real-life practices reported worldwide by an updated website-based survey
Impact of clomiphene citrate during ovarian stimulation on the luteal phase after GnRH agonist trigger
Luteal phase support with estradiol and progesterone versus progesterone alone in GnRH antagonist ICSI cycles: a randomized controlled study
Human luteal phase function following oocyte aspiration from the immediately preovular graafian follicle of spontaneous ovular cycles
Influence of laparoscopic follicular aspiration under general anaesthesia on corpus luteum progesterone secretion in normal and clomiphene-stimulated cycles
Ultrasonic and hormonal evaluation of luteal phases and early ongoing pregnancies after in vitro fertilization and embryo replacement
Luteinizing-hormone-releasing hormone agonist treatment in patients with previously failed folliculogenesis during in vitro fertilization therapy
Extragenomic regulation and autonomous expression of a developmental program in the early mammalian embryo
Hormonal profiles in the follicular phase, luteal phase and first trimester of pregnancies arising from in-vitro fertilization
Urinary oestrogen levels and follicle ultrasound measurements in clomiphene induced cycles with an endogenous luteinizing hormone surge
The recovery of pre-ovulatory oocytes using a fixed schedule of ovulation induction and follicle aspiration
Outcome of in-vitro fertilization and embryo transfer after different regimens of ovarian stimulation
Unexplained infertility and the possibilities of management with in vitro fertilization and embryo transfer
Atosiban and Pregnancy Outcomes Following In Vitro Fertilization Treatment for Infertile Women Requiring One, Two, or More Embryo Transfer Cycles: A Longitudinal Cohort Study
A biophotonic approach to measure pH in small volumes in vitro: quantifiable differences in metabolic flux around the cumulus-oocyte-complex (COC)
Effect of assisted reproductive technology on fetal brain development assessed by prenatal ultrasonography
Ultrasonically guided collection of preovulatory oocytes as a feasible alternative to laparoscopic procedure for human in vitro fertilization
Indications for the treatment of tubal infertility patients by microsurgery or in vitro fertilization
The ReceptIVFity cohort study protocol to validate the urogenital microbiome as predictor for IVF or IVF/ICSI outcome
A controlled study of luteinizing hormone-releasing hormone agonist (buserelin) for the induction of folliculogenesis before in vitro fertilization
Ovarian hyperstimulation syndrome in the 21st century: the role of gonadotropin-releasing hormone agonist trigger and kisspeptin
Protein tyrosine phosphorylation, hyperactivation and progesterone-induced acrosome reaction are enhanced in IVF media: an effect that is not associated with an increase in protein kinase A activation
Preparation of human spermatozoa for in vitro fertilization by isopycnic centrifugation on self-generating density gradients
Comparing different sperm separation techniques for ART, through quantitative evaluation of p53 protein
For the next 40 years of in vitro fertilization-let's sharpen our focus on iatrogenic harm reduction.
The association between level of physical activity and pregnancy rate after embryo transfer: a prospective study.
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