Establishing On-Site Reference Values for (123)I-FP-CIT SPECT (DaTSCAN®) Using a Cohort of Individuals with Non-Degenerative Conditions

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Nicolas NicastroPierre R Burkhard

Abstract

To overcome the issue of reference values for DaTSCAN® requiring healthy controls, we propose an original approach using scans from individuals with non-degenerative conditions performed at one single center following the same acquisition protocol. From a cohort of 970 consecutive patients, we identified 182 patients with a clinical diagnosis of non-degenerative parkinsonism or tremor and a visually normal DATSCAN®. Caudate nucleus (C), putamen (P), and striatum (S) uptake values, C/P ratios, and asymmetry indexes (AI) were calculated using semi-quantitative methods. Outcomes were assessed according to age and gender, and reference limits were established using the percentile approach. A significant negative linear effect of age was found upon striatal nuclei uptake of 0.21-0.22 per decade (6.8%/decade for striatum), whereas a potential gender influence proved unclear. Inferior reference limits were established at the 5th percentile. C/P ratios and AIs were not influenced by age or gender, and superior reference limits were set at the 95th percentile. We here propose a convenient approach to calculate site-specific reference limits for DaTSCAN® outcomes not requiring scanning healthy controls. The method appears to yield robust...Continue Reading

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Citations

Jun 15, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Valentina GaribottoPierre R Burkhard
Jul 17, 2016·Parkinsonism & Related Disorders·Nicolas NicastroPierre R Burkhard
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Jun 3, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Nicolas NicastroPierre R Burkhard
Aug 30, 2018·Journal of Neurology·Gilles AllaliFrederic Assal
Sep 11, 2018·Journal of Clinical Neurology·Nicolas NicastroArmin Schnider
Dec 5, 2018·Brain Imaging and Behavior·Nicolas NicastroValentina Garibotto
Feb 15, 2017·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Enrico PremiA Padovani
Oct 13, 2020·Journal of Parkinson's Disease·Lars FringsPhilipp T Meyer
Jul 23, 2020·Parkinsonism & Related Disorders·Nicolas NicastroValentina Garibotto
Nov 2, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Helen Schmitz-SteinkrügerRalph Buchert
Nov 14, 2021·Alzheimer's Research & Therapy·Arianna SalaDaniela Perani

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