Establishing quality control in the new IVF laboratory

Human Fertility : Journal of the British Fertility Society
Rachel CuttingKaren Martin

Abstract

The ability to create an optimal environment for the culture of oocytes and embryos is important to ensure that embryo viability, and therefore pregnancy outcome, is not compromised. Laboratory performance can be monitored using a quality control system. In setting up a new IVF unit, a comprehensive quality control programme was established to monitor laboratory performance and to detect any problems that potentially may have resulted in a sub-optimal service. The measures employed were designed to optimize the environment for human embryo culture by providing aseptic conditions and security for the gametes and embryos, whilst providing a safe working environment for laboratory staff. Equipment function, consumables and environmental parameters were assessed prior to the commencement of treatment in the new unit. A mouse embryo bioassay was used to assess the ability of the new laboratory and equipment to support mammalian embryo development. Prior to the start of clinical treatments a quality control program highlighted equipment that was functioning sub-optimally, which had the potential to cause problems had it been left undetected. Once clinical treatment commenced, quality control monitoring was continued to ensure that th...Continue Reading

References

Aug 1, 1986·Fertility and Sterility·E Snyman, J V Van der Merwe
Aug 1, 1995·Molecular Reproduction and Development·J BradshawR M Moor
Apr 1, 1995·Molecular Reproduction and Development·K L Martin, H J Leese
Aug 1, 1997·Human Reproduction·J CohenB Dale
Sep 16, 2000·Molecular and Cellular Endocrinology·M Wikland, C Sjöblom

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