Establishing the ferret as a gyrencephalic animal model of traumatic brain injury: Optimization of controlled cortical impact procedures

Journal of Neuroscience Methods
S C SchwerinS L Juliano

Abstract

Although rodent TBI studies provide valuable information regarding the effects of injury and recovery, an animal model with neuroanatomical characteristics closer to humans may provide a more meaningful basis for clinical translation. The ferret has a high white/gray matter ratio, gyrencephalic neocortex, and ventral hippocampal location. Furthermore, ferrets are amenable to behavioral training, have a body size compatible with pre-clinical MRI, and are cost-effective. We optimized the surgical procedure for controlled cortical impact (CCI) using 9 adult male ferrets. We used subject-specific brain/skull morphometric data from anatomical MRIs to overcome across-subject variability for lesion placement. We also reflected the temporalis muscle, closed the craniotomy, and used antibiotics. We then gathered MRI, behavioral, and immunohistochemical data from 6 additional animals using the optimized surgical protocol: 1 control, 3 mild, and 1 severely injured animals (surviving one week) and 1 moderately injured animal surviving sixteen weeks. The optimized surgical protocol resulted in consistent injury placement. Astrocytic reactivity increased with injury severity showing progressively greater numbers of astrocytes within the whit...Continue Reading

References

Jul 1, 1976·Developmental Psychobiology·R HaddadJ W Lazar
Oct 1, 1991·Journal of Neuroscience Methods·C E DixonR L Hayes
Jan 1, 1990·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·E B Cabot, J G Fox
Jan 1, 1990·Journal of Neurotrauma·J W LighthallC R Pinderski
Aug 1, 1989·Stroke; a Journal of Cerebral Circulation·C S AtkinsonB Katz
Jan 1, 1988·Journal of Neurotrauma·J W Lighthall
Aug 1, 1994·Journal of Neurotrauma·T A Gennarelli
Jan 6, 1999·Somatosensory & Motor Research·D F McLaughlinS L Juliano
Jan 29, 2000·Journal of Clinical and Experimental Neuropsychology·D H ShumJ G O'Gorman
Feb 6, 2004·Journal of Neurochemistry·Keiko OhsawaShinichi Kohsaka
Aug 17, 2004·Journal of Neurotrauma·Takamoto SuzukiW Dalton Dietrich
Aug 2, 2005·Neuroreport·Maria Christensson, Martin Garwicz
Mar 1, 2006·Journal of Neurotrauma·Geoffrey T ManleyS Scott Panter
Mar 15, 2006·Archives of Neurology·Rainer ScheidD Yves von Cramon
Sep 1, 2006·Developmental Neuroscience·Ann-Christine Duhaime
Dec 1, 2006·Journal of Neuroscience Methods·Heather D DobbinsDidier A Depireux
Sep 4, 2008·Neuropsychology·Kristy Draper, Jennie Ponsford
Apr 7, 2009·Archives of Physical Medicine and Rehabilitation·Gavin WilliamsPaul R McCrory
Aug 31, 2010·Archives of Physical Medicine and Rehabilitation·Marieke R BenedictusJoukje van der Naalt
Aug 23, 2011·Current Opinion in Pulmonary Medicine·Nicholas W Keiser, John F Engelhardt
Jul 28, 2012·The Journal of Trauma and Acute Care Surgery·Karin A RafaelsAmanda Toman
Dec 13, 2012·Neuropathology and Applied Neurobiology·C SmithJ A R Nicoll
Jan 19, 2013·Nature Reviews. Neuroscience·Ye XiongMichael Chopp
Feb 1, 2013·Brain : a Journal of Neurology·Victoria E JohnsonWilliam Stewart
Dec 18, 2013·Journal of Neuropathology and Experimental Neurology·David J LoaneAlan I Faden
Apr 18, 2014·PloS One·Katharine EakinBarry J Hoffer
Jun 4, 2014·Journal of Neurologic Physical Therapy : JNPT·Erin V L VasudevanAndrew T Packel
Feb 24, 2015·Handbook of Clinical Neurology·Victoria E JohnsonDouglas H Smith

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Citations

Jul 21, 2017·Brain Sciences·Nicole Osier, C Edward Dixon
Mar 6, 2019·Journal of Neurotrauma·William M Armstead, Monica S Vavilala
Mar 26, 2019·Journal of Neurotrauma·Sandy R ShultzRichelle Mychasiuk
Jan 24, 2018·Journal of Neuroscience Research·Susan C SchwerinSharon L Juliano
Jan 10, 2021·Journal of Neuropathology and Experimental Neurology·Susan C SchwerinSharon L Juliano
Jan 18, 2021·Brain : a Journal of Neurology·Cornelius K DonatMazdak Ghajari
Aug 14, 2018·Journal of Neuroscience Methods·Meghann C RyanStephen McGuire
Dec 27, 2017·Journal of Neuroscience Methods·Meghann C RyanStephen A McGuire
May 18, 2021·Frontiers in Cell and Developmental Biology·Carlotta Gilardi, Nereo Kalebic
Jul 14, 2021·Journal of Neuroscience Research·Nicole L AckermansPatrick R Hof

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