Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development.

Wiley Interdisciplinary Reviews. Systems Biology and Medicine
Judith SchütteBerthold Göttgens

Abstract

Transcription factors (TFs) have long been recognized as powerful regulators of cell-type identity and differentiation. As TFs function as constituents of regulatory networks, identification and functional characterization of key interactions within these wider networks will be required to understand how TFs exert their powerful biological functions. The formation of blood cells (hematopoiesis) represents a widely used model system for the study of cellular differentiation. Moreover, specific TFs or groups of TFs have been identified to control the various cell fate choices that must be made when blood stem cells differentiate into more than a dozen distinct mature blood lineages. Because of the relative ease of accessibility, the hematopoietic system represents an attractive experimental system for the development of regulatory network models. Here, we review the modeling efforts carried out to date, which have already provided new insights into the molecular control of blood cell development. We also explore potential areas of future study such as the need for new high-throughput technologies and a focus on studying dynamic cellular systems. Many leukemias arise as the result of mutations that cause transcriptional dysregulat...Continue Reading

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Citations

Dec 18, 2014·Genome Biology·Assieh SaadatpourGuo-Cheng Yuan
Jan 29, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Victoria Moignard, Berthold Göttgens
Jul 12, 2014·Experimental Cell Research·Jonathan I Sive, Berthold Göttgens
Mar 26, 2014·Nature Reviews. Immunology·Damien Chaussabel, Nicole Baldwin

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