Establishing What Constitutes a Healthy Human Gut Microbiome: State of the Science, Regulatory Considerations, and Future Directions

The Journal of Nutrition
Michael I McBurneyMarie E Latulippe

Abstract

On December 17, 2018, the North American branch of the International Life Sciences Institute (ILSI North America) convened a workshop "Can We Begin to Define a Healthy Gut Microbiome Through Quantifiable Characteristics?" with >40 invited academic, government, and industry experts in Washington, DC. The workshop objectives were to 1) develop a collective expert assessment of the state of the evidence on the human gut microbiome and associated human health benefits, 2) see if there was sufficient evidence to establish measurable gut microbiome characteristics that could serve as indicators of "health," 3) identify short- and long-term research needs to fully characterize healthy gut microbiome-host relationships, and 4) publish the findings. Conclusions were as follows: 1) mechanistic links of specific changes in gut microbiome structure with function or markers of human health are not yet established; 2) it is not established if dysbiosis is a cause, consequence, or both of changes in human gut epithelial function and disease; 3) microbiome communities are highly individualized, show a high degree of interindividual variation to perturbation, and tend to be stable over years; 4) the complexity of microbiome-host interactions re...Continue Reading

References

May 23, 1979·Molecular & General Genetics : MGG·R RenkawitzK H Glätzer
Jun 1, 1991·The Journal of Applied Bacteriology·J H Cummings, G T Macfarlane
Jan 1, 1988·Annual Review of Nutrition·D Kritchevsky
Jan 1, 1987·Molecular Aspects of Medicine·H C Trowell, D P Burkitt
Jan 1, 1987·Nutrition and Cancer·M I McBurneyJ L Jeraci
Jun 1, 1988·Applied and Environmental Microbiology·K J WedekindL Montgomery
Jan 1, 1997·Advances in Experimental Medicine and Biology·M I McBurneyK A Tappenden
Feb 6, 1998·FEMS Microbiology Reviews·F von WintzingerodeE Stackebrandt
Nov 10, 2005·Public Health Nutrition·Ingrid H E Rutishauser
Dec 17, 2008·Scandinavian Journal of Gastroenterology·Hans HildebrandScott M Montgomery
Mar 25, 2009·Infection and Immunity·Dionysios A AntonopoulosVincent B Young
Jun 23, 2010·The Quarterly Review of Biology·Mark Vellend
Jul 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jeremy E KoenigRuth E Ley
Nov 16, 2010·International Journal of Food Microbiology·Maija SaxelinKatja Hatakka
Mar 11, 2011·The American Journal of Clinical Nutrition·Wendy R RussellHarry J Flint
Jun 1, 2011·Genome Biology·J Gregory CaporasoRob Knight
Jun 8, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A Marcobal, J L Sonnenburg
Jun 16, 2012·Nature·UNKNOWN Human Microbiome Project Consortium
Sep 14, 2012·Nature·Catherine A LozuponeRob Knight
Dec 12, 2012·Nature·Siegfried SchloissnigPeer Bork
Dec 18, 2012·Immunology·Trevor D Lawley, Alan W Walker
Dec 18, 2012·Journal of Applied Microbiology·D WatsonD van Sinderen
Jan 22, 2013·Trends in Microbiology·Sebastien MatamorosMarie-France de La Cochetiere
Feb 13, 2013·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Meghan B AzadUNKNOWN CHILD Study Investigators
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Dec 26, 2013·Journal of Pediatric Gastroenterology and Nutrition·Isabelle E J A FrançoisWillem F Broekaert
Apr 15, 2014·Nutrition Journal·Julie Miller Jones
Aug 29, 2014·Molecular Nutrition & Food Research·Karen WindeyKristin Verbeke

❮ Previous
Next ❯

Citations

Mar 14, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Sharon M Donovan
Apr 10, 2020·Expert Review of Gastroenterology & Hepatology·Gerard Clarke
Jun 20, 2020·FEMS Microbiology Reviews·Francesca De FilippisDanilo Ercolini
Aug 28, 2020·European Journal of Nutrition·James C GriffithsDaniel S Marsman
Jul 28, 2020·Nutrients·Henry J Thompson
Aug 31, 2019·International Journal of Environmental Research and Public Health·Diego GuidolinLuigi F Agnati
Sep 17, 2020·Nature Communications·Vinod K GuptaJaeyun Sung
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Barbara C SorkinGuido F Pauli
Feb 19, 2020·Digestive Diseases and Sciences·Wenly RuanJames Versalovic
Jul 17, 2020·Frontiers in Microbiology·Susan M WernimontJan S Suchodolski
Jun 19, 2020·Nutrients·Noemí Redondo-UserosAscensión Marcos
Aug 23, 2020·International Journal of Molecular Sciences·Yi-Hsun ChenMing-Shiang Wu
Oct 13, 2020·Frontiers in Microbiology·Shaillay Kumar DograSami Damak
Dec 4, 2020·The Journal of Nutrition·Maria L MarcoMary Ellen Sanders
Jul 25, 2020·Canadian Journal of Physiology and Pharmacology·Dragana StanisicSuresh C Tyagi
Jun 24, 2020·Seminars in Cancer Biology·Nirmala SehrawatAnil K Sharma
Jan 17, 2021·Bulletin of Experimental Biology and Medicine·E V GrigorovaL V Rychkova
Nov 15, 2019·Current Opinion in Rheumatology·Lacey J FavazzoMichael J Zuscik
Jan 25, 2021·Journal of Infection and Public Health·Nicola SerraConsolato Sergi
Feb 8, 2020·Neuroscience and Biobehavioral Reviews·Nathan D NuzumHelen Macpherson
Jan 19, 2021·International Journal of Medical Microbiology : IJMM·Aida IljazovicTill Strowig
Jan 22, 2021·Genome Medicine·Emily R LeemingCaroline I Le Roy
Mar 2, 2021·Experimental Biology and Medicine·Kirsten BerdingJohn F Cryan
Apr 1, 2021·Microbes and Infection·Giuliano BayerDana J Philpott
Apr 13, 2021·ACS Infectious Diseases·Stephen A KellyBrendan F Gilmore
May 1, 2021·Nutrients·Henry J ThompsonMary C Playdon
Mar 18, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alex E MohrKaren L Sweazea
Aug 28, 2021·Nutrients·Tom Baranowski, Kathleen J Motil

❮ Previous
Next ❯

Methods Mentioned

BETA
cesarean sections

Software Mentioned

HELIUS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.