Establishment and characterization of an experimental model of coronary thrombotic microembolism in rats.

The American Journal of Pathology
Ye GuBo Gao

Abstract

To establish a model of coronary thrombotic microembolism in rats, either automicrothrombotic particulates (CM group) or saline control (SHAM group) was injected into temporarily clamped aortas of male Sprague-Dawley rats. After automicrothrombotic particulate injection, serum c-troponin I and von Willebrand factor levels, the no-flow area as evaluated by Thioflavin S, myocardial leukocyte infiltration levels, myocardial expressions of tumor necrosis factor alpha and interleukin-6, the percentage of arterioles obstructed by thrombosis, and myocardial fibrosis were all significantly increased whereas cardiac function as evaluated by echocardiography and hemodynamic measurements were significantly reduced compared with the sham group. Thus, aortic automicrothrombotic particulate injection could induce coronary microembolism in rats, and this model could be of value in improving the understanding of pathophysiology of coronary microembolism.

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Citations

Oct 1, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maythem SaeedMark W Wilson
Jul 26, 2014·Journal of the American College of Cardiology·Won-Keun KimHelge Möllmann
Aug 30, 2011·International Journal of Cardiology·Maythem SaeedMark W Wilson
Jan 30, 2014·The Journal of Vascular Access·Thabata Coaglio LucasGiuliano Brunori
Oct 19, 2013·Experimental and Therapeutic Medicine·Yupeng BaiHong Jiang

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