Establishment and characterization of C-type RNA virus-producing cell lines from radiation-induced murine osteosarcomas

Journal of Cancer Research and Clinical Oncology
V ErfleA Luz

Abstract

Eight cell lines were established from murine osteosarcomas induced in vivo with the radionuclides 224Ra and 227Th. They have been compared by light and electron microscopy, by karyology, and by their growth properties. The morphology, the growth pattern, and the ability to induce tumors in mice indicate that five of them are tumor cell lines. Chromosome studies demonstrated that the five cell lines have marker chromosomes. The other cell lines only showed some criteria generally used to score for transformation of fibroblasts and they may be derived from stromal cells. All cell lines release virus particles in the culture fluid which have the typical properties of RNA tumor viruses. They possess C-type morphology, a density of 1.16--1.18 g/cm3, a 60--70 S RNA, a RNA dependent DNA polymerase and they induce syncytia in rat XC cells. The possible significance of these virus particles in radiation osteosarcomagenesis is discussed.

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Citations

Apr 1, 1990·International Journal of Radiation Biology·M JanowskiP G Strauss
Dec 1, 1988·Differentiation; Research in Biological Diversity·J SchmidtV Erfle
Jan 1, 1985·Acta Radiologica. Oncology·O Dahl
Apr 15, 1988·International Journal of Cancer. Journal International Du Cancer·P G StraussV Erfle
Jul 15, 1986·International Journal of Cancer. Journal International Du Cancer·A SchönV Erfle
Mar 13, 2014·The Cochrane Database of Systematic Reviews·Daniel J JonesSophie V Bell-Syer
Jul 15, 1980·International Journal of Cancer. Journal International Du Cancer·V ErfleA Luz
Feb 1, 1983·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·V ErfleA Mayr

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