Establishment and depletion of the ovarian reserve: physiology and impact of environmental chemicals

Cellular and Molecular Life Sciences : CMLS
Wei GeWei Shen

Abstract

The reproductive life span in women starts at puberty and ends at menopause, following the exhaustion of the follicle stockpile termed the ovarian reserve. Increasing data from experimental animal models and epidemiological studies indicate that exposure to a number of ubiquitously distributed reproductively toxic environmental chemicals (RTECs) can contribute to earlier menopause and even premature ovarian failure. However, the causative relationship between environmental chemical exposure and earlier menopause in women remains poorly understood. The present work, is an attempt to review the current evidence regarding the effects of RTECs on the main ovarian activities in mammals, focusing on how such compounds can affect the ovarian reserve at any stages of ovarian development. We found that in rodents, strong evidence exists that in utero, neonatal, prepubescent and even adult exposure to RTECs leads to impaired functioning of the ovary and a shortening of the reproductive lifespan. Regarding human, data from cross-sectional surveys suggest that human exposure to certain environmental chemicals can compromise a woman's reproductive health and in some cases, correlate with earlier menopause. In conclusion, evidences exist tha...Continue Reading

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Aug 25, 2020·Archives of Toxicology·Pierre CastelBlandine Courbiere
Nov 12, 2020·International Journal of Molecular Sciences·Melanie K StewartAndrew J Pask
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Oct 2, 2021·Journal of Autism and Developmental Disorders·Jill EscherVictor G Corces

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