DOI: 10.1101/487967Dec 5, 2018Paper

Establishment and imaging evaluation of Guangxi Ba-Ma mini pigs as a model of cerebral hernia induced by acute intracranial hypertension

BioRxiv : the Preprint Server for Biology
Jianguo ZhouHuamin Tang

Abstract

Objective: To establish an animal model of cerebral hernia induced by acute intracranial hypertension for subsequent research in emergency medicine. Methods: Six Guangxi Ba-Ma mini-pigs were injected with autologous arterial blood by micropump to induce intracranial hematoma in the frontal and temporal parietal lobes. Changes in intracranial pressure (ICP), mean arterial blood pressure (MAP) and cerebral perfusion pressure (CPP) were observed during hematoma formation. Morphological changes and the occupying effects of intracranial hematoma were analyzed using computed tomography (CT) and magnetic resonance imaging (MRI) of the head. Results: ICP, MAP and CPP gradually increased during blood injection, and they began to slowly decrease at 10 min after injection, though they remained higher than before injection. These three parameters were significantly different before blood injection, immediately after injection and at 10 min after injection (P < 0.05). Head CT and MRI showed cerebral hernia induced by acute intracranial hypertension. Conclusion: Micropump injection of autologous arterial blood can lead to acute intracranial hypertension in mini-pigs, which may be a useful model of cerebral hernia.

Related Concepts

Barium
Blood Pressure
Diagnostic Imaging
Emergency Medicine (Field)
Head
Hematoma
Intracranial Pressure
Magnetic Resonance Imaging
Research
Swine, Miniature

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