Establishment of a cut-point value of serum TNF-alpha levels in the metabolic syndrome.

Journal of Clinical Laboratory Analysis
Carmen M Gurrola-DíazJosé F Muñoz-Valle

Abstract

Cardiovascular diseases and type 2 diabetes are the major causes of mortality in Mexico. Metabolic syndrome (MS) is a cluster of factors that increase the risk to develop such diseases. Previous studies have shown that MS is associated with high tumor necrosis factor (TNF-alpha) levels. In fact, TNF-alpha has been proposed to be a useful marker for clinical diagnosis of inflammation at an early stage. Therefore, we analyzed TNF-alpha concentrations in Mexican individuals with or without MS and related these levels to the associated MS components. Clinical, anthropometric, and biochemical data were analyzed in 41 healthy and 39 MS individuals. Individuals were similarly grouped by age and gender.The serum TNF-alpha levels measured by a highly sensitive enzyme-linked immunosorbent assay (ELISA) kit were increased significantly in MS subjects compared with healthy individuals (P<0.001). The assay showed 78.1% sensitivity and 61.5% specificity with a cut-point level of 1.36 pg/mL. TNF-alpha levels higher than the cut-point value were correlated with insulin resistance indices. These findings support the hypothesis that serum TNF-alpha concentration could be a useful marker for early MS diagnosis. Nevertheless, we suggest the establ...Continue Reading

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Citations

Jul 15, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Francesco FizGianmario Sambuceti
Aug 1, 2018·Metabolic Syndrome and Related Disorders·Ana Ligia Gutiérrez-SolisRosa María Méndez-González
Jul 23, 2019·Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury·R R Berihanova, I A Minenko
Mar 28, 2019·European Journal of Clinical Pharmacology·F HaghighatdoostMitra Hariri

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