Establishment of a Dissolution Test System for the Biorelevant Characterization of Esophageal Applied Dosage Forms.

Journal of Pharmaceutical Sciences
Christoph Maria RosenbaumWerner Weitschies

Abstract

There is a high demand for drug delivery systems that enable local therapy of esophageal diseases such as eosinophilic esophagitis. For the development of such drug delivery systems, suitable in vitro test procedures are needed that allow a biorelevant characterization of dosage forms. With the help of the new test system presented in this thesis it is now possible to simulate the application site esophagus and to characterize the dissolution behavior of esophageal applied drug delivery systems under special consideration of physiological parameters like salivary flow rate, intensity of peristalsis, and posture of the patient. In this work, the dissolution of mucoadhesive films for esophageal application with the new device was investigated and compared to the results obtained with the compendial standard device (USP 2 apparatus). The results show that the novel test system is a promising tool for the early evaluation of locally applied oral formulations for esophageal application.

References

May 9, 2002·International Journal of Pharmaceutics·H K BatchelorD Q M Craig
Mar 24, 2005·Pharmaceutical Research·Hannah Batchelor
Jun 10, 2005·Forensic Science International : Synergy·Johan K M Aps, Luc C Martens
Jun 3, 2010·Physiology & Behavior·Emilie K BeltzerDouglas A Granger
Dec 12, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anroop B NairIbrahim A Alhaider
Jun 19, 2013·Expert Opinion on Drug Delivery·Maren PreisJörg Breitkreutz
Jul 16, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Christina WoertzPeter Kleinebudde
Feb 28, 2016·Digestive Diseases and Sciences·Jody N HefnerSteve B Min
Jan 24, 2017·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kirsten KirschWerner Weitschies
Mar 7, 2017·International Journal of Pharmaceutics·Kirsten KirschWerner Weitschies
Feb 13, 2018·United European Gastroenterology Journal·Alfredo J LucendoÁngel Arias
Dec 19, 2018·AAPS PharmSciTech·Isabell SpeerJörg Breitkreutz
Mar 4, 2019·International Journal of Pharmaceutics·Isabell SpeerJörg Breitkreutz
Aug 12, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Julius KrauseWerner Weitschies

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.