Establishment of a Genomic-Clinicopathologic Nomogram for Predicting Early Recurrence of Hepatocellular Carcinoma After R0 Resection.

Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract
Bin YuYanfeng Wang

Abstract

A high rate of postoperative recurrence, especially early recurrence (ER) occurring within 1 year, seriously impedes patients with hepatocellular carcinoma (HCC) from achieving long-term survival. This study aimed to establish a genomic-clinicopathologic nomogram for precisely predicting ER in HCC patients after R0 resection. Two reliable datasets from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases were selected as the training and validation cohorts, respectively. The prognostic genes related to ER were screened out by univariate Cox regression analysis and differential expression analysis. The gene-based prognostic index was constructed using LASSO and Cox regression analyses, and its independent prognostic value was assessed by Kaplan-Meier and multivariate Cox analyses. Gene set enrichment analysis (GSEA) was performed to explore the biological pathways related to the prognostic index. Finally, the nomogram integrating all the independent prognostic factors was established and comprehensively evaluated by calibration plots, the C-index, receiver operating characteristic curves, and decision curve analysis. Nine dysregulated and prognostic genes related to ER (ZNF131, TATDN2, TXN, DDX55, KPNA2...Continue Reading

References

Aug 4, 2004·Journal of Hepatology·Yukinori KurokawaMorito Monden
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L CampDavid L Rimm
Mar 10, 2007·American Journal of Obstetrics and Gynecology·Eliana BignottiAlessandro D Santin
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ray-Hwang YuanHey-Chi Hsu
May 15, 2008·Journal of the National Cancer Institute·Josep M LlovetUNKNOWN Panel of Experts in HCC-Design Clinical Trials
Jan 27, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Shinichi YoshiokaMorito Monden
Mar 15, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ti ZhangSteven A Curley
Nov 19, 2014·International Journal of Oncology·Nahla ElgoharyThomas Longerich
Apr 30, 2015·Clinics in Liver Disease·Benyam D Addissie, Lewis R Roberts
Dec 29, 2015·Frontiers in Bioscience (Landmark Edition)·Moumita Sarkar, Mrinal Kanti Ghosh
Jul 28, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shengxian YuanWeiping Zhou
Jan 29, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie K HeimbachJorge A Marrero
Jun 7, 2017·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Cong Zhang, Qian Sun
Jul 21, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Matteo DonadonGuido Torzilli
Aug 19, 2017·Science·Mathias UhlenFredrik Ponten
Jan 9, 2018·Lancet·Alejandro FornerJordi Bruix
Mar 6, 2018·Journal of Hepatology·Jean-Charles NaultJens U Marquardt
Apr 10, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Oct 28, 2018·Gastroenterology·Laura Kulik, Hashem B El-Serag
Dec 24, 2018·Journal of Hepatology·Yao-Ming ZhangGao-Min Liu
Jan 18, 2019·International Journal of Cancer. Journal International Du Cancer·Yu WangKam Man Hui
Feb 1, 2019·Chinese Journal of Cancer Research = Chung-kuo Yen Cheng Yen Chiu·Jianling LiuYi Zhang
Apr 16, 2019·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Xiu-Ping ZhangUNKNOWN Chinese National Research Cooperative Group for Diagnosis and Treatment of Hepatocellular Carcinoma with Tumour Thrombus
Jun 14, 2019·Journal of Hepatology·Julien CalderaroJessica Zucman-Rossi
Aug 9, 2019·World Journal of Gastroenterology : WJG·Clifford AkatehJordan M Cloyd

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