Abstract
To determine the feasibility and safety of establishing a porcine hepatic cirrhosis and portal hypertension model by hepatic arterial perfusion with 80% alcohol. Twenty-one healthy Guizhou miniature pigs were randomly divided into three experimental groups and three control groups. The pigs in the three experimental groups were subjected to hepatic arterial perfusion with 7, 12 and 17 mL of 80% alcohol, respectively, while those in the three control groups underwent hepatic arterial perfusion with 7, 12 and 17 mL of saline, respectively. Hepatic arteriography and direct portal phlebography were performed on all animals before and after perfusion, and the portal venous pressure and diameter were measured before perfusion, immediately after perfusion, and at 2, 4 and 6 wk after perfusion. The following procedures were performed at different time points: routine blood sampling, blood biochemistry, blood coagulation and blood ammonia tests before surgery, and at 2, 4 and 6 wk after surgery; hepatic biopsy before surgery, within 6 h after surgery, and at 1, 2, 3, 4 and 5 wk after surgery; abdominal enhanced computed tomography examination before surgery and at 6 wk after surgery; autopsy and multi-point sampling of various liver lob...Continue Reading
References
Jan 1, 1997·Journal of Vascular and Interventional Radiology : JVIR·D PavcnikF S Keller
Sep 25, 2003·Journal of Clinical Gastroenterology·Charles S LieberLeonore M DeCarli
Feb 14, 2007·Journal of Vascular and Interventional Radiology : JVIR·David C MadoffKenneth C Wright
Oct 22, 2008·Chemico-biological Interactions·Sang K KimYoung C Kim
May 25, 2010·Journal of Gastroenterology and Hepatology·Wangxun JinJianmin Li
Oct 20, 2010·Best Practice & Research. Clinical Gastroenterology·Susanne N Weber, Hermann E Wasmuth
Feb 3, 2011·Alcoholism, Clinical and Experimental Research·Victoria K Snowdon, Jonathan A Fallowfield
Apr 19, 2011·Best Practice & Research. Clinical Gastroenterology·Peter Starkel, I A Leclercq
Aug 2, 2011·Journal of Vascular and Interventional Radiology : JVIR·Rony AvritscherDavid C Madoff
Aug 2, 2012·Journal of Gastroenterology and Hepatology·Masaharu SakamotoMichio Sata
Aug 2, 2012·Acta Cirúrgica Brasileira·Thamirys Guimarães MarquesLuiz Augusto Carneiro D'Albuquerque
Oct 10, 2012·Clinical Science·Ching-Chih ChangShou-Dong Lee
Oct 20, 2012·European Journal of Clinical Investigation·Shao-Jung HsuShou-Dong Lee
Jan 1, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yan LiuSteven Dooley
Mar 18, 2015·Nature Reviews. Gastroenterology & Hepatology·Alexandre Louvet, Philippe Mathurin
Apr 3, 2015·Clinical and Molecular Hepatology·Anna S Lok
Citations
Jul 20, 2018·Journal of Complementary & Integrative Medicine·Shreya S RevadiA Mooventhan
Jul 4, 2020·Scientific Reports·Kristoffer KjærgaardMichael Sørensen
Oct 25, 2017·Hepatology International·Jaime Bosch, Yasuko Iwakiri
Jul 15, 2020·Scientific Reports·Yu-Ting HsuPei-Shiue Tsai
Nov 5, 2020·Life Sciences·Yujia MaQiyong Guo