PMID: 2495538Apr 1, 1989Paper

Establishment of a human T-cell clone cytotoxic for both autologous and allogeneic hepatocytes from chronic hepatitis patients with type non-A, non-B virus

Proceedings of the National Academy of Sciences of the United States of America
M ImawariH Nakagama

Abstract

A human T-cell clone (TA-NB-2) that could lyse both autologous and allogeneic hepatocytes from chronic hepatitis patients with type non-A, non-B virus (NANB) was established. This clone produced CD3+ CD8+ cytotoxic T lymphocytes and expressed an antigen specific for alpha and beta subunits of T-cell receptor. The cytotoxic activity of the clone was abrogated by incubation with anti-CD3 monoclonal antibody. Anti-HLA monoclonal antibodies did not block the lysis of the target hepatocytes by TA-NB-2 cells. The cytotoxicity of TA-NB-2 clone against hepatocytes from patients with chronic NANB hepatitis was 39.8 +/- 13.2% (mean +/- SD; n = 17) (range, 14.2-60.5%), whereas that against hepatocytes from control patients with chronic type-B hepatitis, acute hepatitis B, acute hepatitis A, or alcoholic liver cirrhosis was 4.0 +/- 7.7% (n = 12) (range, -10.8 to 14.0%). The results suggest that TA-NB-2 cells specifically recognize a hepatitis NANB-related antigen expressed on hepatitis NANB-infected hepatocytes by T-cell receptor and that the recognition is not restricted by the major histocompatibility complex antigens. The results also suggest that most, if not all, cases of chronic hepatitis due to NANB are caused by one agent; TA-NB-2 ...Continue Reading

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Citations

Jan 1, 1997·Springer Seminars in Immunopathology·K M ChangF V Chisari
Jan 1, 1997·Springer Seminars in Immunopathology·M J Koziel, B D Walker
Sep 1, 1990·Baillière's Clinical Gastroenterology·N Sheron, G J Alexander
Aug 1, 1995·Current Opinion in Immunology·C M Rice, C M Walker
Apr 25, 2000·Virus Research·T Collen, W I Morrison
Mar 1, 1997·Journal of Gastroenterology and Hepatology·M YoshikawaH Fukui
Sep 3, 2008·Journal of Gastroenterology and Hepatology·Kazumasa HiroishiMichio Imawari
Feb 1, 1992·The American Journal of the Medical Sciences·H KanamoriM Yoshiba
Aug 1, 1994·Journal of Hepatology·R P Gonzalez-PeraltaJ Y Lau
Sep 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K HataT L Whiteside
May 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K HataT L Whiteside
Nov 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H KitaM Imawari
Mar 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L García-BueyR Moreno-Otero
Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G RamadoriK H Meyer zum Büschenfelde
Apr 1, 1994·Alimentary Pharmacology & Therapeutics·G M Dusheiko
Jul 1, 1995·Scandinavian Journal of Gastroenterology·R Wejstål

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