Establishment of a modified percutaneous CT-guided paraspinal intramuscular VX-2 squamous cell carcinoma dual tumor model in rabbits.

PeerJ
Liangliang MengYueyong Xiao

Abstract

The rabbit VX-2 tumor model is a commonly used transplanted tumor model and is widely used in surgical, radiological, and interventional studies. Most of the known tumor models for each site are single solid tumors. This study aimed to establish an accurate and stable intramuscular dual tumor model guided by computed tomography (CT). In this study, we compared three different inoculation methods to select the most appropriate dual tumor model. Six New Zealand White rabbits were used as tumor-carrying rabbits for tumor harvesting. Thirty rabbits were divided into three groups as experimental rabbits. Group A applied the tumor cell suspension method, in which the suspension was injected into the designated location with a syringe under CT guidance. Groups B and C used tumor tissue strips obtained in vivo or under direct in vitro vision. The tumor tissue strips were implanted into the designated locations using a guide needle under CT guidance. The differences in tumorigenic rate, the size difference between bilateral tumors, and metastasis between the three methods were compared. It was found that group A obtained a 100% tumor survival rate, but the size of the tumor was more variable, and needle tract implantation metastasis occ...Continue Reading

References

Feb 3, 2009·The Journal of Surgical Research·Kwang-Hun LeeJean-Francois H Geschwind
Aug 18, 2009·The Journal of Urology·Dakun ZhangYongyan Gao
Sep 30, 1935·The Journal of Experimental Medicine·P Rous, J W Beard
Mar 20, 2012·Osteoarthritis and Cartilage·C KilkennyD G Altman
Dec 18, 2013·Immunotherapy·Abhinav Sidana
Feb 5, 2015·Clinical & Experimental Metastasis·Padina S PezeshkiAlbert J M Yee
Aug 20, 2016·IEEE Transactions on Medical Imaging·Avinoam Bar-ZionYonina C Eldar
May 16, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ying-Jin XuJin-Song Zhu
Dec 11, 2020·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Seong Eun KoHyo Keun Lim

❮ Previous
Next ❯

Software Mentioned

SPSS
ARRIVE

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.