PMID: 6986835Jan 1, 1980Paper

Establishment of a new cell line from maxillary sinus carcinoma

The Annals of Otology, Rhinology, and Laryngology
T NakashimaI Hiroto

Abstract

We succeeded in deriving a long-term tissue culture cell line from human maxillary sinus carcinoma. This cell line, designated as MC, was passaged 100 times in vitro over a period of 18 months. The cells are globular in shape, grow as single cells in the culture medium, and the mean population doubling time is about 12 hours. The plating efficiency rate in soft agar is 78% and chromosomal analysis revealed the modal chromosome number to be between 47 and 51. These MC cells were transplanted into five nude mice, all of which developed a tumor after a latency period of 5 to 8 days and died within 39 days. Complete autopsy of all mice revealed no metastasis. Histopathological findings of the original and the transplanted tumor tissues showed a remarkable similarity.

References

Jun 20, 1976·Nihon Jibiinkoka Gakkai kaiho·M Ishida, A Nakajima
Mar 1, 1976·Archives of Otolaryngology·R J EasthamT A Maguda
Oct 1, 1972·The Journal of Clinical Investigation·J WybranH H Fudenberg
Jan 1, 1970·Annual Review of Medicine·A A Sandberg, D K Hossfeld
Nov 1, 1973·Journal of the National Cancer Institute·D J GiardW P Parks
May 1, 1974·Journal of the National Cancer Institute·L OzzelloJ P Mach
Jun 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·G KleinJ Stjernswärd
Jan 1, 1970·International Archives of Allergy and Applied Immunology·R R CoombsB Lindgren

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