Establishment of a rat and guinea pig aortic interposition graft model reveals model-specific patterns of intimal hyperplasia

Journal of Vascular Surgery
Elaine K GregoryMelina R Kibbe

Abstract

Although the aortic interposition bypass model has been widely used to evaluate biomaterials for bypass grafting, there is no comprehensive description of the procedure or of the distribution of intimal hyperplasia that results. The objectives of this study were to (1) review and summarize approaches of aortic interposition grafting in animal models, (2) determine the pertinent anatomy for this procedure, (3) validate this model in the rat and guinea pig, and (4) compare the distribution of intimal hyperplasia that develops in each species. A literature search was performed in PubMed from 1980 to the present to analyze the use of anesthesia, anticoagulation, antiplatelet agents, graft material, suture, and anastomotic techniques. Using 10-week-old male Sprague-Dawley rats and Hartley guinea pigs, we established pertinent aortic anatomy, developed comparable models, and assessed complications for each model. At 30 days, the graft and associated aorta were explanted, intimal formation was assessed morphometrically, and cellularity was assessed via nuclear counting. We reviewed 30 articles and summarized the pertinent procedural findings. Upon establishing both animal models, key anatomic differences between the species that affec...Continue Reading

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Citations

Mar 28, 2018·Scientific Reports·Frédéric F DepreuxDonna S Whitlon
Aug 7, 2018·Journal of Tissue Engineering and Regenerative Medicine·Paolo F SánchezJuan Carlos Briceño
Aug 24, 2021·BioMed Research International·Sarah C StokesAijun Wang

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