Establishment of a rat model for alveolar cleft with bone wax

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Jian SunZhenqi Chen

Abstract

Although treatment of cleft lip and cleft palate is becoming standardized, treatment of alveolar cleft remains controversial. Thus, preclinical animal work remains necessary to improve clinical outcome. This study established an alveolar cleft model in the rat. Maxillary first molars were extracted to create a 4- × 4- × 3-mm complete alveolar cleft on the right and left sides in 25 8-week-old Sprague-Dawley rats. The left cleft was filled with bone wax and the right side remained untreated. Animals were sacrificed at 0, 4 and 8 weeks after surgery. Harvested alveolar cleft samples were evaluated by micro-computed tomographic and histologic analyses. The healing rate and osteoblast activity of the left cleft were less than those of the right cleft. This model of a critical-size alveolar cleft can be used efficiently for the therapeutic evaluation of novel techniques for the treatment of alveolar cleft.

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Citations

May 6, 2019·International Journal of Molecular Sciences·Marcela Martín-Del-CampoLuis Rojo
Feb 27, 2017·Journal of Translational Medicine·Mohammad KamalBernd Lethaus
Aug 17, 2019·Tissue Engineering. Part C, Methods·Masaaki ItoMasaki Honda
Nov 28, 2020·Scientific Reports·Stephan Christian MöhlhenrichAli Modabber

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