Establishment of a secondary infection model of severe acute pancreatitis in swine

Jianhua WangYan Liu


Develop a swine model of secondary infection in severe acute pancreatitis (SAP). Twenty-seven female swine were divided into 3 groups (1-3). In the first experiment, a SAP model was developed by retrograde injection of sodium taurocholate and trypsin into the pancreatic duct. In the second experiment, the SAP model was used to develop a secondary infection model. In groups 1 to 3, 10⁸/mL or 10⁴/mL Escherichia coli or saline were respectively used to inoculate necrotic areas of the pancreas using computed tomographic guidance. Biochemical, histopathological, and imaging analyses were used to characterize disease presentation. The survival rate was 85.2% (23/27) during the course of the 9-day experiment. The secondary infection rates in groups 1 to 3 were 100% (8/8), 37.5% (3/8), and 14.3% (1/7), respectively. In group 1, the infection rate was significantly higher in comparison to the other 2 groups (χ²=4.66 and 8.14, respectively, and both P<0.05). The biochemical and histopathological parameters and computed tomographic images indicated successful development of the SAP secondary infection model. The swine model of SAP secondary infection was successfully developed using a 2-step method, which could serve as a platform for SAP...Continue Reading


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Related Concepts

Taurocholic Acid, Monolithium Salt
Acute Pancreatitis
Benign Tumor of Pancreas
Secondary Infections
Escherichia Coli Infections
Acute Disease
Differential White Blood Cell Count Procedure

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