Establishment of a set of double transfectants coexpressing organic anion transporting polypeptide 1B3 and hepatic efflux transporters for the characterization of the hepatobiliary transport of telmisartan acylglucuronide

Drug Metabolism and Disposition : the Biological Fate of Chemicals
Naoki IshiguroYuichi Sugiyama

Abstract

In the hepatic uptake of organic anions, organic anion transporting polypeptide (OATP) 1B1 is believed to be mainly involved. We have constructed a set of double-transfected cells coexpressing OATP1B1 and hepatic efflux transporters and characterized the transcellular transport of several anions. Recent reports have also suggested the importance of OATP1B3 in the hepatic uptake of some compounds. However, there is little information about OATP1B3-selective substrate and no good tool for the evaluation of efflux transporters of OATP1B3 substrates. In the present study, we found an OATP1B3-selective substrate and established a novel set of double transfectants expressing OATP1B3. Telmisartan acylglucuronide (tel-glu) is a main metabolite of telmisartan, an angiotensin II receptor antagonist. Tel-glu is recognized by hepatobiliary transport systems and efficiently distributed to liver. Several studies using rat and human hepatocytes and transporter-expressing cells revealed that OATP1B3 was responsible for the hepatic uptake of tel-glu in humans. By using double transfectants expressing OATP1B3, we investigated the transcellular transport of tel-glu as well as estradiol 17beta-d-glucuronide (E(2)17betaG) and cholecystokinin octape...Continue Reading

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Citations

Jul 2, 2009·Pharmaceutical Research·Sarah Shugarts, Leslie Z Benet
Feb 5, 2010·Pharmaceutical Research·Sayaka IchiharaYuichi Sugiyama
Jun 22, 2011·Pharmacogenetics and Genomics·Ichiro IeiriYuichi Sugiyama
Aug 7, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Makoto Kataoka
Feb 16, 2010·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kazuya Maeda
Jun 1, 2010·Expert Opinion on Drug Metabolism & Toxicology·Sylvia DeppeRalf A Benndorf
Jan 20, 2010·Drug Metabolism Reviews·Katalin JemnitzPeter Krajcsi
Nov 9, 2014·Expert Opinion on Drug Metabolism & Toxicology·Lori W E van der SchoorJohan W Jonker
Oct 8, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Masatomo MiuraToshio Suzuki
Dec 17, 2009·Basic & Clinical Pharmacology & Toxicology·Leslie Z Benet
Mar 12, 2010·Biopharmaceutics & Drug Disposition·J WeissR A Benndorf
Nov 15, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Katherine S FennerHugh A Barton
Apr 18, 2017·Journal of Pharmaceutical Sciences·Jingjing YuIsabelle Ragueneau-Majlessi
Apr 7, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Toni Schumacher, Ralf A Benndorf
Apr 30, 2017·Journal of Pharmaceutical Sciences·Solène MarieNicolas Tournier
Apr 22, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Renato J ScialisJosé E Manautou
Jan 9, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Soichiro MatsushimaYuichi Sugiyama
Oct 18, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Naoki IshiguroOlaf Schaefer
Jan 11, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Norikazu MatsunagaIkumi Tamai
Sep 2, 2014·Biological & Pharmaceutical Bulletin·Yuji MukaiNobuo Inotsume
Feb 5, 2008·Molecular Pharmacology·Soichiro MatsushimaYuichi Sugiyama
Jun 5, 2020·Clinical Pharmacology and Therapeutics·Päivi HirvensaloMikko Niemi
Apr 29, 2019·Clinical Pharmacokinetics·Merel van NulandJos H Beijnen
Apr 2, 2021·Biochemical Pharmacology·Jonny KinziHenriette E Meyer Zu Schwabedissen

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