Establishment of a streptozotocin-induced diabetic domestic pig model and a systematic evaluation of pathological changes in the hard and soft tissue over a 12-month period

Clinical Oral Implants Research
Cornelius von WilmowskyKarl Andreas Schlegel

Abstract

The number of diabetic patients in need of medical treatment is growing steadily. Therefore, a diabetic animal model with high degree of similarities with humans, which is suitable for the systematic evaluation of biomaterials and medical devices, is needed. Twenty domestic pigs were used for the study. Fifteen received Streptozotocin (STZ) to induce diabetes mellitus. Internal parameters were measured and bone as well as soft tissues biopsies were taken after 0, 6 and 12 months and evaluated qualitatively and quantitatively by means of scanning electronic microscopy, light microscopy and microradiography. The results of the clinical internal parameters, determined by the American Diabetes Association for the definition of diabetes mellitus could be fulfilled. Pathological changes of the skin vasculatures were already visible after 6 months with a significant wall thickening in the diabetic group. The bone mineralization was lower in the diabetic group after 6 months and with a significant difference after 12 months. From the present results, it can be concluded that a STZ dosage of 90 mg/kg body weight in the domestic pig is suitable for the induction of an apparent diabetes, leading to histolopathological changes in the hard ...Continue Reading

References

May 30, 1979·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M Marshall
Oct 1, 1990·The Journal of Surgical Research·R W GruessnerD E Sutherland
Apr 1, 1986·Clinical Orthopaedics and Related Research·J P Schmitz, J O Hollinger
Jan 1, 1988·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M M SwindleB J Hepburn
Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·M MarshallJ Staubesand
Jul 1, 1995·Diabetes·J C KrakauerA M Parfitt
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Oct 22, 1998·The Journal of Craniofacial Surgery·C BoschK Vargervik
Jan 26, 1999·Clinical Orthopaedics and Related Research·D M Nunamaker
Aug 5, 2000·Journal of Diabetes and Its Complications·M SuzukiY Harano
Feb 24, 2001·Journal of Child Neurology·A VerrottiF Chiarelli
Sep 8, 2001·Drug Discovery Today·J Fricker
Mar 12, 2002·Annals of Periodontology·H F MorrisS Winkler
Dec 25, 2002·Medicinal Research Reviews·Alexandra MartinDavid C Sane
Mar 1, 2003·Diabetes Care·Paul HoganUNKNOWN American Diabetes Association
Jul 13, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Karl Andreas SchlegelJörg Wiltfang
Nov 10, 2006·Clinical Oral Implants Research·Karl Andreas SchlegelStephan Rupprecht
Mar 6, 2007·European Cells & Materials·A I PearceS G Pearce
Apr 22, 2008·Clinical Oral Implants Research·Rainer LutzKarl Andreas Schlegel
Sep 10, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Cornelius von WilmowskyKarl Andreas Schlegel

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Citations

Mar 29, 2012·Journal of Inherited Metabolic Disease·Yonglun LuoCharlotte Brandt Sørensen
Feb 26, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Mustafa RamazanogluKarl Andreas Schlegel
May 13, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Zongyang SunMatthew J Allen
Aug 21, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Nikos MardasMichel Dard
Jul 15, 2011·Journal of Clinical Periodontology·Cornelius von WilmowskyKarl Andreas Schlegel
Jul 26, 2012·Journal of Clinical Periodontology·Peterson Antônio Dutra OliveiraPatricia Ramos Cury
Nov 25, 2011·Clinical Oral Implants Research·K A SchlegelC von Wilmowsky
Aug 19, 2014·Journal of Clinical Periodontology·Tobias MoestKarl Andreas Schlegel
May 23, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Cornelius von WilmowskyTobias Moest
Jan 1, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Norman E FrederickPooneh Bagher
May 11, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sujee JeyapalinaKent N Bachus
Dec 20, 2019·Journal of Prosthodontic Research·Seiya YamazakiRyuji Hosokawa
Mar 25, 2018·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Paulo G CoelhoMichel Dard

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