Establishment of a transitory dorsal-biased window of localized Ca2+ signaling in the superficial epithelium following the mid-blastula transition in zebrafish embryos

Developmental Biology
Leung Hang MaAndrew L Miller

Abstract

Using complementary luminescent- and fluorescent-based Ca(2+) imaging techniques, we have re-examined the Ca(2+) dynamics that occur during the Blastula Period (BP) of zebrafish development. We confirm that aperiodic, localized Ca(2+) transients are generated predominately in the superficial epithelial cells (SECs). At the start of the BP, these Ca(2+) transients are distributed homogeneously throughout the entire superficial epithelium. Following the mid-blastula transition (MBT), however, their distribution becomes asymmetrical, where a significantly greater number are generated in the presumptive dorsal quadrant of the superficial epithelium. This asymmetry in Ca(2+) signaling lasts for around 60 min, after which the total number of transients generated from the entire superficial epithelium falls to less than one per minute until the end of the BP. We have thus called this asymmetry the "dorsal-biased Ca(2+) signaling window". The application of pharmacological agents indicates that the post-MBT SEC Ca(2+) transients are generated via the phosphatidylinositol (PI) signaling pathway. This suggests that the previously reported ventralizing function attributed to the homogeneously distributed PI pathway-generated SEC Ca(2+) tr...Continue Reading

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Citations

Oct 12, 2012·PLoS Biology·Shu-Yu WuLilianna Solnica-Krezel
Oct 23, 2014·Journal of Cellular Biochemistry·Fabio ValentiGianfranco Bellipanni
Dec 27, 2011·Biochimica Et Biophysica Acta·Sarah E Webb, Andrew L Miller
Jun 29, 2011·Biochimie·Sarah E WebbAndrew L Miller
Mar 15, 2012·Seminars in Cell & Developmental Biology·Olga Markova, Pierre-François Lenne
Nov 2, 2018·International Journal of Molecular Sciences·Sudip PaudelMargaret Saha
May 3, 2013·Cold Spring Harbor Protocols·Sarah E Webb, Andrew L Miller

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